ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Onset of feeling an injection
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 190175" data-attributes="member: 13851"><p>Definitely not common when it comes to esterified T.</p><p></p><p>Depending on the protocol one is following (dose T used/injection frequency) many would tend to feel something when levels peak (depending on the ester used) and when using the most commonly prescribed esters (cypionate/enanthate) levels will peak 8-12 hrs post-injection.</p><p></p><p>Even then when using enanthate/cypionate T levels will start rising (sharp increase) within 2 hrs post-injection.</p><p></p><p>Many who have tried unesterified T such as suspension or oil-based T pre-workout would tell you that they notice an increase in energy/mood/drive/aggression.</p><p></p><p>The same would apply to one of the oldest oral C-17 alpha-alkylated compounds methyltestosterone which had been used by many athletes (boxers, football players, powerlifters strongmen) pre-event to increase energy/drive/aggression.</p><p></p><p>I am using twice-weekly injections (enanthate) and I always feel amped up 12 hrs post-injection and a definite boost in mood/libido.</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>Comparative pharmacokinetics of testosterone enanthate and testosterone cyclohexanecarboxylate as assessed by serum and salivary testosterone levels in normal men</strong> <strong><span style="color: rgb(184, 49, 47)">(1984)</span></strong></p><p><span style="color: rgb(44, 130, 201)">By Th. Schurmeyer and E. Nieschlag </span></p><p></p><p></p><p></p><p></p><p><span style="color: rgb(184, 49, 47)"><em>The pharmacokinetics of 2 testosterone esters, testosterone enanthate, and testosterone cyclohexane carboxylate, were compared in a single-blind crossover study in healthy young men.</em></span> Their effects on serum and salivary levels of testosterone, as well as on the serum levels of LH, FSH, and prolactin were measured after the injection of doses equivalent to 140 mg free testosterone. <span style="color: rgb(184, 49, 47)"><em>Both preparations yielded <u>supraphysiological testosterone levels in serum and saliva as early as <strong>2 h following injection</strong>, reaching peak levels 4 to 5 times above basal between 8 and 24 h</u>.</em></span> LH and FSH levels were suppressed as long as serum testosterone levels were elevated. Nine days after injecting testosterone enanthate and 7 days after giving testosterone cyclohexane carboxylate, serum and salivary levels of testosterone had returned to basal. The longer activity of testosterone enanthate was also evidenced by more extended suppression of gonadotrophin levels. Although neither preparation is ideal because of the initial supraphysiological peaks, testosterone enanthate appears preferable for clinical use because of its slightly longer duration of action.</p><p></p><p></p><p></p><p></p><p><strong>Study Design and Methods </strong></p><p></p><p>Seven healthy men aged 22-31 years gave written consent to participate in the study after its purpose and possible risks had been explained in detail. Four volunteers chosen at random first received testosterone cyclohexane carboxylate, followed 5 weeks later by a testosterone enanthate injection. The other 3 volunteers received testosterone enanthate first and testosterone cyclohexane carboxylate 5 weeks later. <span style="color: rgb(184, 49, 47)"><em>For baseline values, a blood sample was obtained several days prior to the first injection, and another blood sample was taken immediately before the testosterone preparation was injected im. <u>Further blood samples were obtained 2 and 8 h after the injection and then daily between 8 and 10 a.m. from days 1 to 5, every second day from days 5 to 15, and every third day from days 15 to 21. For every serum sample, a matched saliva sample was obtained.</u> </em></span>Saliva was collected without stimulation of salivary flow over 5 to 20 min by having the volunteers spit into a glass tube. Serum and saliva samples were stored at -20°C prior to analysis. Commercially available testosterone ester preparations were used containing 200 mg testosterone enanthate (Schering AG, Berlin/Bergkamen, FRG) in 0.8 ml oil or 200 mg testosterone cyclohexanecarboxylate (Dr. Thilo & Co. GmbH, Sauerlachi Munchen, FRG) in 2 ml oil. The amount of testosterone in each preparation was the same, namely 140 mg. Expressed in relation to size the testosterone dose administered to the 7 volunteers ranged from 72 to 77 mg/ml.</p><p></p><p></p><p><strong>Discussion </strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><em>Injection of either testosterone enanthate or testosterone cyclohexanecarboxylate in equivalent doses yielded increased serum and salivary testosterone concentrations and <u>supraphysiological levels were achieved as early as 2 h after injection</u>.</em></span> Statistical analysis of the data shows that testosterone enanthate injection results in slightly higher serum testosterone levels for several days after injection and that this ester also suppresses gonadotrophins for a longer period than testosterone cyclohexanecarboxylate. <span style="color: rgb(184, 49, 47)"><em>Pharmacokinetic studies with radioactively labeled testosterone enanthate have shown that it is <u>the rate of absorption from the site of injection, rather than cleavage of the esterified side chain, which limits the flux of testosterone into the bloodstream</u> (Sokol et al. 1981). </em></span>Neither the slightly altered side chain of testosterone cyclohexanecarboxylate compared with testosterone enanthate nor the 2.5 fold larger injection volume of the preparation resulted in a longer-lasting effect.</p><p></p><p><em><span style="color: rgb(184, 49, 47)">The pharmacokinetic properties of testosterone enanthate measured in the present study are in good agreement with published reports (Nieschlag et al. 1976; Schulte-Beerbiihl & Nieschlag 1981; Sokol et al. 1982). <u>Previously it was shown that testosterone cypionate yielded identical serum testosterone levels to those obtained using testosterone enanthate</u>. </span></em>In the present study testosterone cyclohexanecarboxylate given in an equivalent, the dose was effective for a somewhat shorter period of time. Alterations either in the testosterone ester, in the vehicle, or in the route of administration appear necessary to achieve a more physiological pattern of testosterone levels when substituting androgens.</p><p></p><p>Sokol et al. (1981) have shown that after an injection of testosterone enanthate both the esterified testosterone and the hydrolyzed free testosterone appear in the circulation. Since neither the circulating testosterone ester nor its effect on the free testosterone fraction, which diffuses into the target tissue, are detected by measuring total serum testosterone levels, we measured salivary testosterone, which correlates well with free testosterone and provides a good measure of the steroid available to target tissues (Wang et al. 1981). Previously we have shown that the high amounts of testosterone undecanoate circulating in blood after oral administration of this testosterone ester did not result in any additional increase in tissue testosterone levels as represented by the salivary levels of testosterone (Schurmeper et al. 1983). Similarly, testosterone enanthate and testosterone cyclohexanecarboxylate also cause parallel increases in serum and salivary levels of testosterone i.e. the circulating ester does not cause an additional increase in steroid available to the tissue due to cleavage at the target organ.</p><p></p><p><span style="color: rgb(184, 49, 47)"><em>The salivary testosterone levels also show that <u>the supraphysiological peaks of serum testosterone which occur soon after the injection of the testosterone esters are matched by increases in free testosterone</u>. <u>Thus, the sharp increase in testosterone directly following the injection is not buffered by sex hormone-binding globulin or other plasma proteins. Nor are sudden decreases of serum testosterone levels compensated for by testosterone bound to serum proteins</u> (Schurmeyer & Nieschlag 1982). </em></span>Thus, androgen-target tissues are exposed to the same fluctuations in testosterone concentrations as those seen in the total levels in serum. This emphasizes once again the need for new testosterone preparations which are capable of maintaining more constant and more physiological serum levels of testosterone.</p><p></p><p></p><p>[ATTACH=full]11461[/ATTACH]</p><p><strong>Fig. I. <span style="color: rgb(184, 49, 47)">Serum and salivary levels of testosterone in 5 normal men following intramuscular injection of either 200 mg testosterone enanthate </span><span style="color: rgb(0, 0, 0)">(closed circles) </span><span style="color: rgb(184, 49, 47)">or 200 mg testosterone cyclohexanecarboxylate </span><span style="color: rgb(0, 0, 0)">(open circles) </span></strong></p><p></p><p></p><p></p><p>The Antares Subcutaneous Testosterone Enanthate Auto-Injector study (2019) shows T levels peaking 10 hrs post-injection.</p></blockquote><p></p>
[QUOTE="madman, post: 190175, member: 13851"] Definitely not common when it comes to esterified T. Depending on the protocol one is following (dose T used/injection frequency) many would tend to feel something when levels peak (depending on the ester used) and when using the most commonly prescribed esters (cypionate/enanthate) levels will peak 8-12 hrs post-injection. Even then when using enanthate/cypionate T levels will start rising (sharp increase) within 2 hrs post-injection. Many who have tried unesterified T such as suspension or oil-based T pre-workout would tell you that they notice an increase in energy/mood/drive/aggression. The same would apply to one of the oldest oral C-17 alpha-alkylated compounds methyltestosterone which had been used by many athletes (boxers, football players, powerlifters strongmen) pre-event to increase energy/drive/aggression. I am using twice-weekly injections (enanthate) and I always feel amped up 12 hrs post-injection and a definite boost in mood/libido. [B]Comparative pharmacokinetics of testosterone enanthate and testosterone cyclohexanecarboxylate as assessed by serum and salivary testosterone levels in normal men[/B] [B][COLOR=rgb(184, 49, 47)](1984)[/COLOR][/B] [COLOR=rgb(44, 130, 201)]By Th. Schurmeyer and E. Nieschlag [/COLOR] [COLOR=rgb(184, 49, 47)][I]The pharmacokinetics of 2 testosterone esters, testosterone enanthate, and testosterone cyclohexane carboxylate, were compared in a single-blind crossover study in healthy young men.[/I][/COLOR] Their effects on serum and salivary levels of testosterone, as well as on the serum levels of LH, FSH, and prolactin were measured after the injection of doses equivalent to 140 mg free testosterone. [COLOR=rgb(184, 49, 47)][I]Both preparations yielded [U]supraphysiological testosterone levels in serum and saliva as early as [B]2 h following injection[/B], reaching peak levels 4 to 5 times above basal between 8 and 24 h[/U].[/I][/COLOR] LH and FSH levels were suppressed as long as serum testosterone levels were elevated. Nine days after injecting testosterone enanthate and 7 days after giving testosterone cyclohexane carboxylate, serum and salivary levels of testosterone had returned to basal. The longer activity of testosterone enanthate was also evidenced by more extended suppression of gonadotrophin levels. Although neither preparation is ideal because of the initial supraphysiological peaks, testosterone enanthate appears preferable for clinical use because of its slightly longer duration of action. [B]Study Design and Methods [/B] Seven healthy men aged 22-31 years gave written consent to participate in the study after its purpose and possible risks had been explained in detail. Four volunteers chosen at random first received testosterone cyclohexane carboxylate, followed 5 weeks later by a testosterone enanthate injection. The other 3 volunteers received testosterone enanthate first and testosterone cyclohexane carboxylate 5 weeks later. [COLOR=rgb(184, 49, 47)][I]For baseline values, a blood sample was obtained several days prior to the first injection, and another blood sample was taken immediately before the testosterone preparation was injected im. [U]Further blood samples were obtained 2 and 8 h after the injection and then daily between 8 and 10 a.m. from days 1 to 5, every second day from days 5 to 15, and every third day from days 15 to 21. For every serum sample, a matched saliva sample was obtained.[/U] [/I][/COLOR]Saliva was collected without stimulation of salivary flow over 5 to 20 min by having the volunteers spit into a glass tube. Serum and saliva samples were stored at -20°C prior to analysis. Commercially available testosterone ester preparations were used containing 200 mg testosterone enanthate (Schering AG, Berlin/Bergkamen, FRG) in 0.8 ml oil or 200 mg testosterone cyclohexanecarboxylate (Dr. Thilo & Co. GmbH, Sauerlachi Munchen, FRG) in 2 ml oil. The amount of testosterone in each preparation was the same, namely 140 mg. Expressed in relation to size the testosterone dose administered to the 7 volunteers ranged from 72 to 77 mg/ml. [B]Discussion [/B] [COLOR=rgb(184, 49, 47)][I]Injection of either testosterone enanthate or testosterone cyclohexanecarboxylate in equivalent doses yielded increased serum and salivary testosterone concentrations and [U]supraphysiological levels were achieved as early as 2 h after injection[/U].[/I][/COLOR] Statistical analysis of the data shows that testosterone enanthate injection results in slightly higher serum testosterone levels for several days after injection and that this ester also suppresses gonadotrophins for a longer period than testosterone cyclohexanecarboxylate. [COLOR=rgb(184, 49, 47)][I]Pharmacokinetic studies with radioactively labeled testosterone enanthate have shown that it is [U]the rate of absorption from the site of injection, rather than cleavage of the esterified side chain, which limits the flux of testosterone into the bloodstream[/U] (Sokol et al. 1981). [/I][/COLOR]Neither the slightly altered side chain of testosterone cyclohexanecarboxylate compared with testosterone enanthate nor the 2.5 fold larger injection volume of the preparation resulted in a longer-lasting effect. [I][COLOR=rgb(184, 49, 47)]The pharmacokinetic properties of testosterone enanthate measured in the present study are in good agreement with published reports (Nieschlag et al. 1976; Schulte-Beerbiihl & Nieschlag 1981; Sokol et al. 1982). [U]Previously it was shown that testosterone cypionate yielded identical serum testosterone levels to those obtained using testosterone enanthate[/U]. [/COLOR][/I]In the present study testosterone cyclohexanecarboxylate given in an equivalent, the dose was effective for a somewhat shorter period of time. Alterations either in the testosterone ester, in the vehicle, or in the route of administration appear necessary to achieve a more physiological pattern of testosterone levels when substituting androgens. Sokol et al. (1981) have shown that after an injection of testosterone enanthate both the esterified testosterone and the hydrolyzed free testosterone appear in the circulation. Since neither the circulating testosterone ester nor its effect on the free testosterone fraction, which diffuses into the target tissue, are detected by measuring total serum testosterone levels, we measured salivary testosterone, which correlates well with free testosterone and provides a good measure of the steroid available to target tissues (Wang et al. 1981). Previously we have shown that the high amounts of testosterone undecanoate circulating in blood after oral administration of this testosterone ester did not result in any additional increase in tissue testosterone levels as represented by the salivary levels of testosterone (Schurmeper et al. 1983). Similarly, testosterone enanthate and testosterone cyclohexanecarboxylate also cause parallel increases in serum and salivary levels of testosterone i.e. the circulating ester does not cause an additional increase in steroid available to the tissue due to cleavage at the target organ. [COLOR=rgb(184, 49, 47)][I]The salivary testosterone levels also show that [U]the supraphysiological peaks of serum testosterone which occur soon after the injection of the testosterone esters are matched by increases in free testosterone[/U]. [U]Thus, the sharp increase in testosterone directly following the injection is not buffered by sex hormone-binding globulin or other plasma proteins. Nor are sudden decreases of serum testosterone levels compensated for by testosterone bound to serum proteins[/U] (Schurmeyer & Nieschlag 1982). [/I][/COLOR]Thus, androgen-target tissues are exposed to the same fluctuations in testosterone concentrations as those seen in the total levels in serum. This emphasizes once again the need for new testosterone preparations which are capable of maintaining more constant and more physiological serum levels of testosterone. [ATTACH type="full" alt="Screenshot (2442).png"]11461[/ATTACH] [B]Fig. I. [COLOR=rgb(184, 49, 47)]Serum and salivary levels of testosterone in 5 normal men following intramuscular injection of either 200 mg testosterone enanthate [/COLOR][COLOR=rgb(0, 0, 0)](closed circles) [/COLOR][COLOR=rgb(184, 49, 47)]or 200 mg testosterone cyclohexanecarboxylate [/COLOR][COLOR=rgb(0, 0, 0)](open circles) [/COLOR][/B] The Antares Subcutaneous Testosterone Enanthate Auto-Injector study (2019) shows T levels peaking 10 hrs post-injection. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Onset of feeling an injection
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top