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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Onset of feeling an injection
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<blockquote data-quote="Cataceous" data-source="post: 190149" data-attributes="member: 38109"><p>I believe you. Although I don't personally detect testosterone esters, I know that with testosterone propionate my serum level is peaking in a couple hours post-injection, plus or minus, so clearly it's rising rapidly after that first hour, if not before. It wouldn't surprise me if serum testosterone is rising nearly as fast with cypionate or enanthate. There may be some pushback on this because some studies may contradict the idea. But if you look at the basic bi-exponential model for absorption and consumption of testosterone esters you find that the time of peak serum testosterone is mostly dependent on the metabolic rate constant rather than on the much longer absorption rate constant. The testosterone esters control the absorption rate, not the metabolic rate.</p><p></p><p>It wouldn't be too hard for you to perform a blinded test to see if you really are detecting rising testosterone. You'd need to load one syringe with your testosterone and another with a placebo. The placebo would just be a sterile carrier oil that is indistinguishable from the one used with your testosterone. Someone would give you one of the syringes at random. 60-90 minutes post-injection you'd have to state which one you thought it was. Then you could inject the second syringe and after another 60-90 minutes see if you're sticking with your selection. Ideally this procedure would be repeated several times to see what your success rate is.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 190149, member: 38109"] I believe you. Although I don't personally detect testosterone esters, I know that with testosterone propionate my serum level is peaking in a couple hours post-injection, plus or minus, so clearly it's rising rapidly after that first hour, if not before. It wouldn't surprise me if serum testosterone is rising nearly as fast with cypionate or enanthate. There may be some pushback on this because some studies may contradict the idea. But if you look at the basic bi-exponential model for absorption and consumption of testosterone esters you find that the time of peak serum testosterone is mostly dependent on the metabolic rate constant rather than on the much longer absorption rate constant. The testosterone esters control the absorption rate, not the metabolic rate. It wouldn't be too hard for you to perform a blinded test to see if you really are detecting rising testosterone. You'd need to load one syringe with your testosterone and another with a placebo. The placebo would just be a sterile carrier oil that is indistinguishable from the one used with your testosterone. Someone would give you one of the syringes at random. 60-90 minutes post-injection you'd have to state which one you thought it was. Then you could inject the second syringe and after another 60-90 minutes see if you're sticking with your selection. Ideally this procedure would be repeated several times to see what your success rate is. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Onset of feeling an injection
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