Off-Label Use of Xiaflex for Peyronie's Disease

[madman]

Jesse N. Mills, MD, Associate Clinical Professor and Director of the Men’s Clinic at UCLA discusses techniques for Xiaflex on and off label, and when and how it can be used to treat Peyronie’s disease. These include alternative injection techniques, plaques involving the penile urethra, use for men on anticoagulation treatments, and non-goniometric deformity.

 

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Outcomes Of A Novel Penile Traction Device (Restorex) In Men With Peyronie's Disease: A Randomized, Single-Blinded, Controlled Trial - Excel Male TRT Forum

Outcomes Of A Novel Penile Traction Device (Restorex) In Men With Peyronie's Disease: A Randomized, Single-Blinded, Controlled Trial. Ziegelmann M, Savage J, Toussi A, Alom M, Yang D, Kohler T, Trost L Outcomes Of A Novel Penile Traction Device (Restorex) In Men With Peyronie's...

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The use of ultrasonography in the evaluation and management of peyronie’s disease - Excel Male TRT Forum

Objective: To outline the steps in the ultrasonographic evaluation of Peyronie’s disease and determine its use in the diagnosis, classification, and treatment of this disorder. Design: Video presentation Setting: Outpatient Urology clinic. Patient(s): All patients with Peyronie’s disease...

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Treating Peyronie’s disease with platelet-rich plasma - Excel Male TRT Forum

University of Miami Miller School of Medicine researchers are about to start recruiting for the first U.S. clinical trial looking at treating Peyronie’s disease, a painful and agonizing condition common in men, with platelet-rich plasma (PRP)...

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Characteristics predictive of response to CCH for PD - Excel Male TRT Forum

Characteristics predictive of response to collagenase clostridium histolyticum for Peyronie’s disease: a review of the literature Abstract PurposeTo evaluate characteristics predictive of successful treatment outcomes of Peyronie’s disease (PD) with collagenase clostridium histolyticum (CCH)...

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Office-based Treatments for Peyronie's Disease - Excel Male TRT Forum

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Peyronie’s Disease and Erectile Dysfunction : Restorative and Regenerative Therapies - Excel Male TRT Forum

Restorative and Regenerative Therapies for Peyronie’s Disease and Erectile Dysfunction – An Evidence-based Approach to Stem Cells, Shockwave Therapy, and PRP (2021)

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Does Your Penis CURVE? - Excel Male TRT Forum

Peyronie's Disease (also known as PD) is a scarring disorder that can cause a man's penis to curve. This can cause pain with erection, deformity, and make sex difficult or even impossible! Affecting up to 1 in 10 men, PD is much more common than most people think. Although...

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Penile Stretching as a Treatment for Peyronie’s Disease: A Review - Excel Male TRT Forum

ABSTRACT Introduction: Peyronie’s disease (PD) is a debilitating condition that affects a sizable number of men worldwide. Current treatment options consist of oral therapy, intralesional injections, and surgery. Penile stretching has been used as a treatment for PD, including penile traction...

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A clinical pathway for the management of Peyronie’s disease - Excel Male TRT Forum

A clinical pathway for the management of Peyronie’s disease: integrating clinical guidelines from the International Society of Sexual Medicine, American Urological Association and European Urological Association Objective To provide a clinical framework and key guideline statements to assist...

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Peyronie’s disease (Bent Penis): What to do we know and how do we treat it? - Excel Male TRT Forum

Introduction: Peyronie’s disease is a common, benign condition characterized by an acquired penile abnormality due to fibrosis of the tunica albuginea. This may lead to penile curvature, deformity, discomfort, pain, and erectile dysfunction, resulting in emotional and psychosocial effects on...

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Methylprednisolone for treatment of Peyronie’s disease - Excel Male TRT Forum

ABSTRACT Aim There are a few types of drugs that can be used in the active phase of Peyronie’s disease. Methylprednisolone is a corticosteroid with a strong anti-inflammatory effect. In this study, we aimed to evaluate the effect of intralesional low dose methylprednisolone treatment on...

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Treatment for Peyronie's Disease to improve ED - Excel Male TRT Forum

Peyronie’s disease: new paradigm for the treatment of a unique cause of erectile dysfunction Culley Carson ABSTRACT Peyronie’s Disease is an incurable condition of the tunica albuginea of the penis associated with scarring, plaque formation, and penile deformity on erection. It is often...

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Peyronie Disease - Excel Male TRT Forum

Peyronie disease is a common, treatable medical condition that affects millions of men in the US Peyronie disease (PD) is an abnormality of the erect penis such as a bend, curve, or hourglass-shaped narrowing which can negatively affect sexual function. PD can cause pain (with or without...

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Outcomes of RestoreX (PTT) in Men With PD - Excel Male TRT Forum

Outcomes of RestoreX Penile Traction Therapy in Men With Peyronie’s Disease: Results From Open Label and Follow-up Phases ABSTRACT Background: A randomized, controlled clinical trial evaluating the efficacy of RestoreX traction therapy in men with Peyronie’s disease (PD) has been completed...

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3D-Printed Flexible Penile Model Simulator for PIG for PD - Excel Male TRT Forum

ABSTRACT Introduction: Plaque incision and graft (PIG) is suggested for the treatment of significant Peyronie’s disease (PD), but most surgeons perform very few PIG surgeries annually, and the number of PD cases requiring PIG is inadequate to maintain the necessary skills and completely master...

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Peyronie’s disease: pharmacological treatments and limitations - Excel Male TRT Forum

Abstract Introduction: Peyronie’s disease (PD) is a disorder of the tunica albuginea from the disordered and excessive deposition of collagen resulting in a palpable scar, pain, erect penile deformity, and erectile dysfunction that significantly impacts patients both physically and...

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Graft of buccal mucosa restores erections in men with Peyronie's Disease - Excel Male TRT Forum

Summary Introduction: Plaque incision and grafting represent the best surgical approach to Peyronie’s Disease (PD). The grafting procedures must be restricted to patients with normal preoperative status, excessive curvature, and/or deformities. However, the ideal graft has not been identified...

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Conservative Therapy for Peyronie’s Disease - Excel Male TRT Forum

Abstract Purpose of Review To analyze the literature on current conservative treatment options for Peyronie’s disease (PD). Recent Findings Conservative therapy with intralesional collagenase clostridium histolyticum (CCH) is safe and efficacious in either the acute or chronic phases of PD...

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Implications of Calcification in Peyronie’s Disease - Excel Male TRT Forum

A common characteristic of Peyronie’s Disease (PD) is plaque calcification, which is associated with decreased response to treatments and higher rates of surgical intervention. Despite its prevalence in the PD population, the literature on plaque calcification is limited. While the diagnosis of...

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Continuing CCH Injections Among Initial Nonresponders Results in Significant Curvature Improvements in PD men - Excel Male TRT Forum

ABSTRACT Background: It is currently unclear if men with Peyronie's Disease (PD) who achieve minimal benefits with the first 2 series of Collagenase Clostridium Histolyticum (CCH) injections should continue with additional injections. Aim: To analyze curvature improvements from the final...

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Molecular Mechanisms and Current Pharmacotherapy of Bent Penis (Peyronie's Disease) - Excel Male TRT Forum

Peyronie’s disease (PD) is a localized fibrotic lesion of the penis that has adverse effects on men’s health. In this review, we summarized the molecular mechanisms and pharmacotherapies of PD. A literature search was conducted using PubMed and Cochrane Library during 2001–2020. Although no oral...

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Peyronie’s Disease and Erectile Dysfunction : Restorative and Regenerative Therapies - Excel Male TRT Forum

Restorative and Regenerative Therapies for Peyronie’s Disease and Erectile Dysfunction – An Evidence-based Approach to Stem Cells, Shockwave Therapy, and PRP (2021)

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Office-based Treatments for Peyronie's Disease - Excel Male TRT Forum

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Surgical Reconstruction of Penile Curvature due to PD by Plaque Incision and Buccal Mucosa Graft - Excel Male TRT Forum

ABSTRACT Background/aim: We aimed to evaluate the effectiveness and safety of penile plaque incision and buccal mucosa grafting in patients with stable-phase Peyronie’s disease (PD). Methods: This was a prospective evaluation of patients with stable-phase PD who were treated by plaque...

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The Use of Penile Traction Devices for Bent Penis ( Peyronie's Disease)

ABSTRACT Introduction: Penile traction therapy (PTT) aims to non-surgically reduce curvature, enhance girth, and recover lost length. Available clinical practice guidelines however lack clear recommendations regarding their use. Aim: To present a comprehensive review and recommendation...

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Grayscale Ultrasonography of Penile Corporal Fibrosis - Excel Male TRT Forum

INTRODUCTION Ultrasonography (US) is the primary imaging modality used for patients with penile conditions such as erectile dysfunction (ED), Peyronie’s disease (PD), penile trauma, and priapism. While patients are typically given a preliminary diagnosis based on history and physical...

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The mechanisms and potential of stem cell therapy for penile fibrosis - Excel Male TRT Forum

Abstract Fibrosis is often caused by chronic tissue injury leading to a persisting inflammatory response with excessive accumulation of extracellular connective tissue proteins. Peyronie’s disease, urethral stricture, and penile (corpora cavernosa) fibrosis are localized fibrotic disorders of...

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Patient Satisfaction with Extra-Tunical Graft for Peyronie’s Disease (graphic pics) - Excel Male TRT Forum

ABSTRACT Objectives: To report our initial experience with the extra-tunical grafting (ETG) procedure. This procedure was recently introduced by UCSF investigators as a tunica-sparing technique for the management of penile concavity deformities. Methods: We retrospectively reviewed records...

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The evolution in the surgical management of Peyronie’s disease (GRAPHIC PICS) - Excel Male TRT Forum

Abstract Peyronie’s disease (PD) is due to a fibrotic alteration of the tunica albuginea of the penis. It is responsible for penile pain, angulation, and possible erectile dysfunction (ED). Despite almost three centuries have passed since the first description of the disease, etiology still...

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Bent Penis: CCH delivers incremental benefits - Excel Male TRT Forum

https://www.urologytimes.com/view/collagenase-clostridium-histolyticum-delivers-incremental-benefits-across-treatment-cycles-for-peyronie-s-disease Men receiving collagenase clostridium histolyticum (CCH, Xiaflex) for Peyronie’s disease appeared to have incremental benefits from each of 4...

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Penile Injection Therapy: Overview and how to perform injections - Excel Male TRT Forum

Dr. Ryan Flannigan is a Canadian Urologist trained in sexual and reproductive medicine and surgery. He offers sub-specialized evidence-based care for Peyronie's disease, erectile dysfunction, male infertility, and vasectomy reversals. This video provides an overview of intracavernosal...

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Erectile Dysfunction, Priapism, Premature Ejaculation, and Peyronie's Treatments - Excel Male TRT Forum

Dr. John P. Mulhall MD discusses sexual medicine review for the in-service exam

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ESSM Position Statement on Surgical Treatment of Peyronie's Disease

Abstract Introduction: Patients with Peyronie’s disease may experience significant distress. The choice of treatment depends on a variety of factors, including the stage of the disease, the presence of pain, severity, and direction of the curvature, penile length, and the quality of erectile...

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Mineralized Peyronie’s plaque has a phenotypic resemblance to bone - Excel Male TRT Forum

Abstract Mineralized Peyronie’s plaque (MPP) impairs penile function. The association, colocalization, and dynamic interplay between organic and inorganic constituents can provide insights into the biomineralization of Peyronie's plaque. Human MPPs (n = 11) were surgically excised, and the...

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ED Can Cause Peyronie disease - Excel Male TRT Forum

Peyronie disease (PD), first reported in 1743 as a disease,1 is now recognized in most cases to be the result of coital trauma to the penis. In 1997, Devine et al suggested that poor rigidity during penetrative sex causes delamination of the elastic covering (tunica albuginea) of the penile...

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Peyronie’s Disease: state of the art of clinical answers - Excel Male TRT Forum

This ISSM Webinar will be about Peyronie’s Disease: state of the art of clinical answers. Peyronie's disease is a common condition that is arguably underdiagnosed and undertreated. In recent years, several novel therapies have been developed and which have greatly improved outcomes and...

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Peyronie's Disease - Excel Male TRT Forum

Dr. Amy Pearlman is the Clinical Assistant Professor of Urology and Men's Health Program Professor. In this webinar, she covers Peyronie's Disease with her patient Dennis Wallace.

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Contemporary and Emerging Pharmacotherapies for Peyronie’s Disease (Bent Penis) - Excel Male TRT Forum

Pharmacotherapy in Peyronie’s disease: a state-of-the-art review on established contemporary and emerging drugs (2022) Eric Chung & Faysal A. Yafi ABSTRACT Introduction: Current clinical guidelines on Peyronie’s disease (PD) advocate non-surgical treatment options as the first-line...

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Technological Advancements for Treating ED and PD - Excel Male TRT Forum

Technological Advancements for Treating Erectile Dysfunction and Peyronie’s Disease (2022) Jeffrey D. Campbell, MD, MPH*, Danny Matti, Haider Abed, MD, Andrew Di Pierdominico, MD INTRODUCTION Erectile dysfunction (ED) affects 30% to 65% of men in the general population between the ages of 40...

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(GRAPHIC) Complex Penile Surgery: Plication, Grafting, and Implants

Complex Penile Surgery Plication, Grafting, and Implants (2022) Ziho Lee, MD, Jolie Shen, MD, Hunter Wessells, MD INTRODUCTION The pathophysiology of penile defects requiring surgical reconstruction may be classified into injuries of the soft tissue and skin, tunica albuginea (TA), and...

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Peyronie's Self-Assessment App - Excel Male TRT Forum

https://apps.apple.com/us/app/peyronies-self-assessment/id1636482107 This App is intended for men age 18+ who may be concerned about a curve in their penis, allowing the user to document their curvature in the privacy of their own home and contact a physician for evaluation. This curvature may...

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Peyronie’s Disease and Testosterone - Excel Male TRT Forum

Peyronie’s Disease and Testosterone: A Narrative Review (2022) Douglas Schneider, Andrew S. Afyouni, and Faysal A. Yafi* Abstract The pathophysiology of Peyronie’s disease (PD) remains incompletely understood; current hypotheses point to a combination of predetermined genetic factors and...

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Peyronie’s Disease - Excel Male TRT Forum

Peyronie’s Disease (2022) Fabrizio Palumbo, Francesco Sebastiani, Alessandro Procacci, Nicola D’Altilia, Anna Ricapito, and Luigi Cormio 6.1 Introduction Peyronie’s disease (PD), also known as induration penis plastica (IPP), is a clinical condition characterized by the formation of fibrotic...

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Analysis of Peyronie’s Disease Injection Techniques - Excel Male TRT Forum

https://www1.statusplus.net/misc/videos/issm/issm-smsna2022/search/video/?url=https://vimeo.com/756746033&redirect=pm

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Thread 'Peyronie's - How the Comfort Grip May Transform Your RestoreX Experience'

Apr 20, 2025

Join board-certified urologist Dr. Amy Pearlman as she interviews Richard Connell, the innovative mind behind The Comfort Grip—a game-changing new attachment for the RestoreX penile traction device.

This newly released add-on eliminates the need for traditional clamping by comfortably gripping the tip of the penis. Say goodbye to the tedious setup with gauze, makeup pads, and coban wrap. Patients are calling it revolutionary—and we think you’ll agree.

Whether you’re a patient, provider, or just curious about the future of penile traction...

• madman
• peyronie's; ed; sexual health
• Replies: 3
• Forum: When TRT Is Not Enough (ED, Libido, & More)

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