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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
NORMAL E2 AFTER 10 WEEKS OF HCG BUT BREAST PAIN?
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<blockquote data-quote="xqfq" data-source="post: 156604" data-attributes="member: 38167"><p>I haven't done all the research yet, but I think it's unlikely that progesterone in the normal male range would cause breast growth; in fact, it may help <em>stop</em> estrogen from causing gyno!</p><p></p><p>Progesterone itself isn't responsible for the majority of breast growth - estrogen is. Girls going through puberty first experience an increase of estrogen -- without (!) progesterone -- and then experience an increase in progesterone once the breast can support ductal development.</p><p></p><p>If progesterone was present at first (in numbers higher than estrogen) it could stop estrogen from growing the breasts. At least that's what I'm learning:</p><p></p><p>[ATTACH=full]8117[/ATTACH]</p><p>I'm not sure of what the level of progesterone is to create this ductal development, but I suspect it is very, very high relative to the male range. Note that almost all men will have much more progesterone than estrogen.</p><p></p><p>---</p><p></p><p>RE: keithc2485's question - I am not sure why HCG causes gyno symptoms with normal E2 levels in some men but I have read stories of it in this forum and others. If I was forced to guess, one idea I had is:</p><p></p><p>HCG may increase DHEA in some men. DHEA has a metabolite, <strong>Androstenediol</strong>, which acts as an estrogen (activates the estrogen receptor), while itself not "being" E2. So maybe this plays a role[1].</p><p></p><p>-----</p><p>1. From Wikipedia, "It has approximately 6% and 17% of the affinity of estradiol at the ERα and ERβ, respectively. Although androstenediol has far lower affinity for the ERs compared to the major estrogen estradiol, it circulates at approximately 100-fold higher concentrations, and so is thought may play a significant role as an estrogen in the body." (<a href="https://en.wikipedia.org/wiki/Androstenediol" target="_blank">Androstenediol - Wikipedia</a>)</p></blockquote><p></p>
[QUOTE="xqfq, post: 156604, member: 38167"] I haven't done all the research yet, but I think it's unlikely that progesterone in the normal male range would cause breast growth; in fact, it may help [I]stop[/I] estrogen from causing gyno! Progesterone itself isn't responsible for the majority of breast growth - estrogen is. Girls going through puberty first experience an increase of estrogen -- without (!) progesterone -- and then experience an increase in progesterone once the breast can support ductal development. If progesterone was present at first (in numbers higher than estrogen) it could stop estrogen from growing the breasts. At least that's what I'm learning: [ATTACH=full]8117[/ATTACH] I'm not sure of what the level of progesterone is to create this ductal development, but I suspect it is very, very high relative to the male range. Note that almost all men will have much more progesterone than estrogen. --- RE: keithc2485's question - I am not sure why HCG causes gyno symptoms with normal E2 levels in some men but I have read stories of it in this forum and others. If I was forced to guess, one idea I had is: HCG may increase DHEA in some men. DHEA has a metabolite, [B]Androstenediol[/B], which acts as an estrogen (activates the estrogen receptor), while itself not "being" E2. So maybe this plays a role[1]. ----- 1. From Wikipedia, "It has approximately 6% and 17% of the affinity of estradiol at the ERα and ERβ, respectively. Although androstenediol has far lower affinity for the ERs compared to the major estrogen estradiol, it circulates at approximately 100-fold higher concentrations, and so is thought may play a significant role as an estrogen in the body." ([URL='https://en.wikipedia.org/wiki/Androstenediol']Androstenediol - Wikipedia[/URL]) [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
NORMAL E2 AFTER 10 WEEKS OF HCG BUT BREAST PAIN?
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