Night sweats! Accutane

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Nomad

Active Member
I got my normal labs from defy all of my hormones are great, I feel great, but I’ve been getting night sweats.

I’d there any particular I should test for or is this just the nature of the side effects of the very harsh drug?
 
Defy Medical TRT clinic doctor
Just stop the anastrozole. The night sweats will resolve.


im scared to. I get emotional with high e2 and long long before I started TRT. I developed the tiniest of lumps behind one nipple. It gets sensitive and itches. I don’t think insurance covers removal.

I’ve also heard high e2 causes night sweats. I take 28mg testosterone Daily 200mg a week and .1 armidex at the same time.
 
During the pandemic I also ran out of HCG for a month and went hyper sexual for 2 weeks and then when I restarted a month later I went hyper sexual for another two weeks which was very surprising.
 
Gynecomastia only occurs in men with genetic predisposition AND with low T. If you are on TRT, changes are minimal unless you are on suboptimal T cream or gel therapy that does not boost your T.
 
Gynecomastia only occurs in men with genetic predisposition AND with low T. If you are on TRT, changes are minimal unless you are on suboptimal T cream or gel therapy that does not boost your T.

thank you for the responses! and for founding such an amazing site and community before I found this website I was at the mercy of getting information on steroid related forums.
 
You are welcomed. We have been doing this for a long time and many guys here are science nerds like me. :)
Don’t forget to download my latest free book here: BeyondTestosterone.com
 
You are welcomed. We have been doing this for a long time and many guys here are science nerds like me. :)
Don’t forget to download my latest free book here: BeyondTestosterone.com

Nelson I take .1mg anastrozzle once a day So, .7 a week. I stopped taking it yesterday, do you think if I get bloodwork again next Friday it will reflect what my e2 will sit on?

Current medications.
T Cyp 200 mg/ml – 0.14 ml SQ Daily
HCG 500 iu SQ twice a week
Anastrozole 0.1mg daily
Metformin XR 500mg twice daily
DHEA 25mg nightly
Vitamin D3 10,000 iu daily
Fish Oil 3grams daily
Boron 9mg daily.
Accutane 20mg daily with 20g of fats


also, I wish we could have signatures on the forums, where we can all put our current protocols, i filled it out in my profile but it doesn’t show on posts.
 
Nelson I take .1mg anastrozzle once a day So, .7 a week. I stopped taking it yesterday, do you think if I get bloodwork again next Friday it will reflect what my e2 will sit on?

Current medications.
T Cyp 200 mg/ml – 0.14 ml SQ Daily
HCG 500 iu SQ twice a week
Anastrozole 0.1mg daily
Metformin XR 500mg twice daily
DHEA 25mg nightly
Vitamin D3 10,000 iu daily
Fish Oil 3grams daily
Boron 9mg daily.
Accutane 20mg daily with 20g of fats


also, I wish we could have signatures on the forums, where we can all put our current protocols, i filled it out in my profile but it doesn’t show on posts.

You keep posting your protocol but you are leaving out the most important piece of information which would be blood work.

Where does such protocol have your TT/FT/e2 levels?

You are using a whopping dose of T 28mg daily (196mg/week) along with 500IU hCG (twice weekly) which surely must have your TT/FT levels really high let alone your e2.

Although you stated you feel great it seems odd that you need to use an aromatase inhibitor let alone Accutane (due to acne) which would tell me your T levels are really high.

Acne and any e2 issues could in most cases be remedied by running slightly lower TT/FT levels.

Unless your numbers are not as high as I would think on such protocol and you are one who is overly sensitive to testosterone.
 

I go to a TRT clinic I was on 240mg test c / .5 armidex .500 HCG week. Inject just once weekly. Last labs had my total t at 982 on day 7, e2 at 47. I had the labs drawn because I lost my libido and have been suffering from ED.

You were the one who was started on a horrible protocol of once-weekly injections with a whopping dose of T 240mg/week which had your trough way high 908-982 ng/dL 7 days post-injection.

Your peak TT/FT/e2 levels must have been through the roof.

How could anyone have felt good?

You eventually dropped the dose to 200mg/week (100mg every 3.5 days).

Every single thread you have on the forum you keep posting your protocol but leave out the most important part which is lab work.

How do you expect to get any positive feedback from leaving this out?

Luckily you found a better doctor but even though you made the switch to dailies the dose of T you are injecting is very high 28mg (196mg/week) + 500IU hCG (twice weekly) and I find it hard to believe that your TT/FT levels would not be really high.

Most can easily drop the overall weekly dose of T and still achieve a healthy TT/FT level when switching over to daily injections.

Trust me when I tell you there is more to acne than just e2 levels.
 
Last edited:

DHT and Androgenic Side Effects

"In some regards, this local potentiation of testosterone's activity may be unwelcome, as higher androgenic activity in certain tissues may produce a number of undesirable side effects. Acne, for example, is often triggered by dihydrotestosterone activity in the sebaceous glands, and the local formation of dihydrotestosterone in the scalp is typically blamed for triggering male pattern hair loss. You should know that it is a terrible misconception among bodybuilders that dihydrotestosterone is an isolated culprit when it comes to these side effects. All anabolic/androgenic steroids exert their activities, both anabolic and androgenic, through the same cellular androgen receptor"

"Dihydrotestosterone is no different than any other steroid except that it is a more potent activator of this receptor than most, and can be formed locally in certain androgen-sensitive tissues. All steroids can cause androgenic side effects in direct relation to their affinity for this receptor, and DHT has no known unique ability in this regard"

The main point to keep in mind regarding acne or hair loss (genetically prone individuals).....is that DHT is not the sole contributor and it is the general activation of the AR that is responsible.

As Nelson stated any AAS other than testosterone can result in acne in genetically prone individuals.
 

I go to a TRT clinic I was on 240mg test c / .5 armidex .500 HCG week. Inject just once weekly. Last labs had my total t at 982 on day 7, e2 at 47. I had the labs drawn because I lost my libido and have been suffering from ED.

You were the one who was started on a horrible protocol of once-weekly injections with a whopping dose of T 240mg/week which had your trough way high 908-982 ng/dL 7 days post-injection.

Your peak TT/FT/e2 levels must have been through the roof.

How could anyone have felt good?

You eventually dropped the dose to 200mg/week (100mg every 3.5 days).

Every single thread you have on the forum you keep posting your protocol but leave out the most important part which is lab work.

How do you expect to get any positive feedback from leaving this out?

Luckily you found a better doctor but even though you made the switch to dailies the dose of T you are injecting is very high 28mg (196mg/week) + 500IU hCG (twice weekly) and I find it hard to believe that your TT/FT levels would not be really high.

Most can easily drop the overall weekly dose of T and still achieve a healthy TT/FT level when switching over to daily injections.

Trust me when I tell you there is more to acne than just e2 levels.

I’ve posted my old labs before I’ll screen shot the new ones, the numbers are almost identical. I’m naturally high shbg to get it lowered required higher dosing to get my free t where I felt my best.

Yeah my acne got worse at one point but, I’ve suffered with acne since I was 12, I’m 35 now. Even when my total T was was less than 300 it was bad. The acne is something I’m just completely sick of now that I actually have a sex drive. This is the clearest my skin has ever been now since I was a kid.
 

DHT and Androgenic Side Effects

"In some regards, this local potentiation of testosterone's activity may be unwelcome, as higher androgenic activity in certain tissues may produce a number of undesirable side effects. Acne, for example, is often triggered by dihydrotestosterone activity in the sebaceous glands, and the local formation of dihydrotestosterone in the scalp is typically blamed for triggering male pattern hair loss. You should know that it is a terrible misconception among bodybuilders that dihydrotestosterone is an isolated culprit when it comes to these side effects. All anabolic/androgenic steroids exert their activities, both anabolic and androgenic, through the same cellular androgen receptor"

"Dihydrotestosterone is no different than any other steroid except that it is a more potent activator of this receptor than most, and can be formed locally in certain androgen-sensitive tissues. All steroids can cause androgenic side effects in direct relation to their affinity for this receptor, and DHT has no known unique ability in this regard"

The main point to keep in mind regarding acne or hair loss (genetically prone individuals).....is that DHT is not the sole contributor and it is the general activation of the AR that is responsible.

As Nelson stated any AAS other than testosterone can result in acne in genetically prone individuals.

I just looked through all my labs my dht has never been tested, I’ll add that to my next test. I’ve never done steroids I’m just barely 160 pounds at 5’7 I’m not interested in bodybuilding I want functionally fit and healthy only.

edit. My skin has seldom ever been oilyfor me it was about my skin shedding rate. Retin A helped my face a lot but it’s not something I could’ve put on my back myself etc
 
Total T 998
Free T 28.3
SHBG 36.6
E2 43.2


Not as high as I thought even with the addition of the hCG.

Those are e2 numbers on the AI?

Have no idea where your FT truly sits on such dose as I highly doubt you tested using an accurate method (Equilibrium Dialysis or Ultrafiltration).




 
Yeah. When my SHBG dropped in half my e2 rose by a lot. I was high SHBG high E2 before I started TRT.

Not as high as I thought even with the addition of the hCG.

Those are e2 numbers on the AI?

Have no idea where your FT truly sits on such dose as I highly doubt you tested using an accurate method (Equilibrium Dialysis or Ultrafiltration).




 
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