New Urologist wants to get me off testosterone cypionate for Clomid.

Current Protocol

T Cypointate - .5ml Every 4-5 days.



I started with a urologist who specializes in male fertility so I feel like I'm in the right place. They guy seems to know his stuff.

That said, he was very quick to make a protocol to get me off of T after me explaining I do want to have kids someday. I've been on testosterone for eight years, now 38 years old. My baseline previous to going on T was less than 250 most of the time. I had mild depression, weight gain, and low libido. I was never prescribed anything else.

What are your thoughts on my coming off of it and running a sperm analysis after 3 months? I fully expect a crash along with negative side effects from Clomid so I'm pretty worried.

He's prescribed:
Discontinue TRT; +

50mg Clomid 3x per week
1000mg Pregnyl 3x per Week
 
I do want to have kids someday.
If you’re not interest in having children right now, then there’s little reason to subject yourself to potential side effects of clomid and ruining what a success you’ve had for the last eight years.

When you’re ready for kids, then consider clomid.

Also, being on TRT doesn’t automatically mean you’re infertile.

Why not run a sperm analysis now?
 
Last edited:
I am just a bit younger than you and recently had a similar experience with a new endo switching me from TRT (gel) to clomid. It’s been absolutely horrible. T went thru the roof but so did estrogen and he won’t prescribe arimidex. Got increased depression, ed (actually it killed erections completely), fatigue, hot flashes. I highly recommend you go see someone else. I had to start anti depressants and Cialis. I’m switching to Defy.

Many years ago, while already in TRT, Defy helped me get sperm and semen parameters up with hcg + hmg injections. It worked great - libido increased, erections were rock hard, and got the wife pregnant within a month and a half!!

My personal recommendation: avoid clomid, go to a TRT/Men’s/Aging clinic like defy instead.
 
Current Protocol

T Cypointate - .5ml Every 4-5 days.



I started with a urologist who specializes in male fertility so I feel like I'm in the right place. They guy seems to know his stuff.

That said, he was very quick to make a protocol to get me off of T after me explaining I do want to have kids someday. I've been on testosterone for eight years, now 38 years old. My baseline previous to going on T was less than 250 most of the time. I had mild depression, weight gain, and low libido. I was never prescribed anything else.

What are your thoughts on my coming off of it and running a sperm analysis after 3 months? I fully expect a crash along with negative side effects from Clomid so I'm pretty worried.

He's prescribed:
Discontinue TRT; +

50mg Clomid 3x per week
1000mg Pregnyl 3x per Week
If you read many of the case studies on this site, getting to a good place on TRT is by no means a certainty. So, if you are in a good place, I would be very hesitant to change anything until there is a very strong reason to do so. You might not be able to get back to where you were if you change. The body likes consistency. And sadly, having all the pieces fall into place to be in a good situation to have kids is also by no means a guarantee, especially these days. If you have been on for 8 years, staying on longer seems unlikely to hurt your chances of regaining fertility, but I know of no studies on this.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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