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I’ve seen a lot of recent posts by doctors claiming that you should not manage estradiol, and should let it seek it’s own level, and that there is no harm in estrogen for men – but rather benefits. This may be true, but if the goal of hormone replacement is to achieve the hormonal panel of a healthy 25-year-old male – I don’t believe there is any one in that population with E2 over 35 or so. Personally, I keep a low AI regiment and try to keep E2 no higher than upper 30s.