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I had a consult at Defy today. A few interesting theories for what may be going on with me. First, nighttime RHR has been slowly normalizing. Sleep is still disastrously bad.

• Nandrolone can apparently decrease thyroid binding proteins, so the PA speculated that my levels of free thyroid hormones may have increased and that is causing some sleep disruption. I'm still waking up with an elevated heart rate a few times throughout the night. Based on half life calculators I've still got a few weeks before the nandrolone is out of my system.
• One of the PAs thoughts was that I was just taking way too much nandrolone for how sensitive I seem to be. Some of the symptoms I described to him sounded like what guys get when they take too much testosterone, so if I ever were to try nandrolone again (once I get the symptoms resolved and have 6 stable months) it would be at MUCH lower doses, maybe 1/4 of what I was on before.
• He also thinks that even though my sensitive E2 lab value was okay, that my Free E2 may be too high due to lower SHBG and causing issues for me with constipation, water retention, etc.
• He wasn't overly concerned about the elevated creatinine, especially since the rest of the electrolyte values looked OK. I linked him to a rat study that shows creatinine increasing along with nandrolone administration. We're going to watch that value over time.
• He's starting me on spironolactone to see if it can both help with water retention as well as raise SHBG a bit.
• If that fails, he wants to try me on 0.1mg of anastrozole to see if I get symptom relief.
• I'm continuing with the 140mg/week of testosterone cypionate divided into EOD shots, administered subQ.

Still no answers, still feeling shitty!