New drug increases human life span by 30%, according to Mayo Clinic

Vince

Super Moderator
Scientists may never find the elixir of life, but they are finding new ways to extend our life spans. One day, protecting our cells from aging may be as easy as taking a pill. Mayo Clinic researchers say senolytic drugs can boost a key protein in the body that may protect older people against aspects of aging and a range of diseases. Their findings, which are published in eBioMedicine demonstrate this in mice and human studies.



Senolytics developed at Mayo Clinic and given once clear the bloodstream of senescent or "zombie" cells. These cells contribute to multiple diseases and negative aspects of aging. This study shows that the removal of senescent cells significantly boosts the production of a protective protein called a-klotho.

 
The title is rigged. The studies did not show "the new drug" increased HUMAN lifespan. It was actually gene therapy in mice.

The actual medical article itself, is very clear that many of the conjectures in it are "interpretations" of the data. They are also very clear that they have FINANCIAL interest in supporting the patents of the studied senolytics.

One of the senolytics is Dasatinib plus Quercetin. Dasatinin is a leukemia immune suppressor with possible dangerous side effects so I don't see how that will get any use, unless in already sick people.

Quercetin alone was not studied - either doesn't work well or it's just cannot be monetized.

The third alleged senolytic is Fisetin, which currently has shaky safety studies - it interferes with cell division ...
 

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Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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