Natesto Effects on Testosterone, LH, FSH and Semen Parameters

FDA Approved Natesto Nasal Gel to Treat Men with Low Testosterone

FDA Approved Natesto Nasal Gel to Treat Men with Low Testosterone

Natesto Nasal Gel - Update on this with my opinion so far.

Natesto Nasal Gel - Update on this with my opinion so far.


I have a few friends that have been using Natesto for a while and they are doing well overall.....the only downfall would be the 3 time/day application (mind you it is extremely quick and easy) and some men do develop irritation/discomfort of the nasal cavity tissue where it is applied but symptoms usually reside after steady use.

After initial application testosterone levels spike into the upper-normal physiological range/lower supra-physiological range temporarily for a short time than level off and physiological levels are maintained throughout the daily with a daily application (2-3 times/day).

I would think that with the short-term peaks and fluctuations throughout the day there is minimal suppression to LH and FSH along with maintenance of spermatogenesis as opposed to injections.

The ebb and flow of testosterone levels throughout the 24 hr period may play a part.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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