Nasal spray for low testosterone preserves fertility

Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters - Full Text View - ClinicalTrials.gov






Aytu Biosciences funded it!




Natesto Effects on Reproductive Hormones and Semen Parameters: Results from an Ongoing Single-center, Investigator-initiated Phase IV Clinical Trial

Thomas Masterson *, Manuel Molina, Emad Ibrahim, Ranjith Ramasamy

Department of Urology, University of Miami, Miami, FL, USA






"We launched our clinical trial to evaluate the role of Natesto on semen parameters and reproductive hormones in November 2017 with the intent of enrolling 40 participants (Mobile and Remote Monitoring of Seating Pressure for Wheelchair Users With SCI - Full Text View - ClinicalTrials.gov NCT03203681). It is an ongoing, single-institution, prospective investigator-initiated study funded by Aytu Biosciences. Men eligible for the study are aged 18–55 yr, with at least two T levels <350 ng/dl (drawn before 10 AM) and have two semen analyses (SA) with total motile sperm count (TMSC) >5 million. All men are naïve to T therapy prior to enrolment"
 

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hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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