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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone for CRPS/RSD
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<blockquote data-quote="PAUL-E" data-source="post: 38373" data-attributes="member: 13108"><p>One of the links is no longer working so I copyed it <a href="http://webcache.googleusercontent.com/search?q=cache:http://www.dissertationtopic.net/doc/1856753&num=1&strip=1&vwsrc=0" target="_blank">http://webcache.googleusercontent.com/search?q=cache:http://www.dissertationtopic.net/doc/1856753&num=1&strip=1&vwsrc=0</a></p><p>.</p><p>Experimental Research of Nandrolone Phenylpropionate in the Treatment of CRPS on the Rat Model</p><p>Author: YangYang</p><p>Tutor: NanFeng</p><p>School: Dalian Medical University</p><p>Course: Surgery</p><p>Keywords: complex regional pain syndrome nandrolone phenylpropionate salmon calcitonin substance P bone mineral density</p><p>CLC: R965</p><p>Type: Master's thesis</p><p>Year: 2012</p><p>Downloads: 8</p><p>Quote: 0</p><p>Read: Download Dissertation</p><p>Abstract</p><p>Objective: This research is intended to evaluate the analgesic effect of nandrolone phenylpropionate on the rat model of complex regional pain syndrome, and briefly discuss the analgesic mechanism of the nandrolone phenylpropionate, so as to provide the experimental evidence for clinical application of phenylpro-pionate nandrolone in the treatment of complex regional pain syndrome. Methods: Forty-eight healthy adult SD rats were randomly divided into four groups equally. Rats were anesthetized over a3h period with chloral hydrate. After induction of anesthesia, a O-ring with5mm internal diameter was placed around the rat’s right hind limb just proximal to the ankle joint. The O-rings were selected to produce a tight-fit pressure about350mmHg,and were left on the limb for3h. The rats in the sham group received exactly the same treatment,except that the O-ring loosely surrounded the ankle, and did not occlude blood flow to the hind paw. Rats of group B were injected with1ml sterile water intraperitoneally every other day, to days-21aftersurgery. Rats of group C were injected with salmon calcitonin(2IU/Kg) intraperitoneally, every other day, to days-21after surgery. And rats of group D were injected with nandrolone phenylpropionate (5mg/Kg) intraperitoneally, every other day, to days-21after surgery. Then general observation, pain behavior, serum substance P, and distal bone mineral density of the tibia were measured at the specific observation points. By the above indicators, assessing the analgesic effect of nandrolone phenylpropionate on rat model of complex regional pain syndrome. All experimental data were analyzed by the software of SPSS12.0.Results:1.General observation: After modeling, the rats in group B, C and D had a limping gait. At weeks-3after surgery, the claudication symptom of the rats in group C and D was better than the rats in group B. And the rats in group B had epilation and scaling phenomenon.2.Spontaneous pain: At one day after the modeling, spontaneous pain was checked. The spontaneous pain of injured group is more serious than the group A(p<0.05).3.Mechanically induced pain: Since the7days after modeling, the pain threshold of group C and D was significantly higher than group B(p<0.05). To days-21aftersurgery, no significant difference was found between the two treatment groups and group A. At each observation point, no significant difference was found between group C and group D.4.Paw withdrawal latency: Since the7days after modeling, the paw withdrawal latency of group C and D was significantly higher than group B (p<0.05),but always lower than group A. At each observation point, no significant difference was found between group C and group D.5.Substance P: Since the7days after modeling, the level of substance P of group C and D was significantly lower than group B(p<0.05), but always higher than group A. At each observation point, no significant difference was found between group C and group D.6.The tibia Ca2+average density testing: At twenty-one days after the modeling, the distal Ca2+average density of the right tibia of group B is significantly lower than group A(p<0.05). No significant difference was found in other groups.Conclusion:1.Ischemia reperfusion model can simulate the pathophysiological process of CRPS, and modeling process is easy to operate.2.Since the7days after modeling, nandrolone phenylpropionate can signifi-cantlyimprove pain behavior index of the experimental animal, and reduce the expression of substance P.3.Nandrolone phenylpropionate can increase the local Ca2+average density and muscle strength of experimental animal, and prevent the development of CRPS. <u><strong>In summary, the study shows that nandrolone phenylpropionate has a good effect on CRPS with the rat model. So the clinical efficacy of nandrolone phenylpropionate is worthy of further experimental study. </strong></u></p></blockquote><p></p>
[QUOTE="PAUL-E, post: 38373, member: 13108"] One of the links is no longer working so I copyed it [URL]http://webcache.googleusercontent.com/search?q=cache:http://www.dissertationtopic.net/doc/1856753&num=1&strip=1&vwsrc=0[/URL] . Experimental Research of Nandrolone Phenylpropionate in the Treatment of CRPS on the Rat Model Author: YangYang Tutor: NanFeng School: Dalian Medical University Course: Surgery Keywords: complex regional pain syndrome nandrolone phenylpropionate salmon calcitonin substance P bone mineral density CLC: R965 Type: Master's thesis Year: 2012 Downloads: 8 Quote: 0 Read: Download Dissertation Abstract Objective: This research is intended to evaluate the analgesic effect of nandrolone phenylpropionate on the rat model of complex regional pain syndrome, and briefly discuss the analgesic mechanism of the nandrolone phenylpropionate, so as to provide the experimental evidence for clinical application of phenylpro-pionate nandrolone in the treatment of complex regional pain syndrome. Methods: Forty-eight healthy adult SD rats were randomly divided into four groups equally. Rats were anesthetized over a3h period with chloral hydrate. After induction of anesthesia, a O-ring with5mm internal diameter was placed around the rat’s right hind limb just proximal to the ankle joint. The O-rings were selected to produce a tight-fit pressure about350mmHg,and were left on the limb for3h. The rats in the sham group received exactly the same treatment,except that the O-ring loosely surrounded the ankle, and did not occlude blood flow to the hind paw. Rats of group B were injected with1ml sterile water intraperitoneally every other day, to days-21aftersurgery. Rats of group C were injected with salmon calcitonin(2IU/Kg) intraperitoneally, every other day, to days-21after surgery. And rats of group D were injected with nandrolone phenylpropionate (5mg/Kg) intraperitoneally, every other day, to days-21after surgery. Then general observation, pain behavior, serum substance P, and distal bone mineral density of the tibia were measured at the specific observation points. By the above indicators, assessing the analgesic effect of nandrolone phenylpropionate on rat model of complex regional pain syndrome. All experimental data were analyzed by the software of SPSS12.0.Results:1.General observation: After modeling, the rats in group B, C and D had a limping gait. At weeks-3after surgery, the claudication symptom of the rats in group C and D was better than the rats in group B. And the rats in group B had epilation and scaling phenomenon.2.Spontaneous pain: At one day after the modeling, spontaneous pain was checked. The spontaneous pain of injured group is more serious than the group A(p<0.05).3.Mechanically induced pain: Since the7days after modeling, the pain threshold of group C and D was significantly higher than group B(p<0.05). To days-21aftersurgery, no significant difference was found between the two treatment groups and group A. At each observation point, no significant difference was found between group C and group D.4.Paw withdrawal latency: Since the7days after modeling, the paw withdrawal latency of group C and D was significantly higher than group B (p<0.05),but always lower than group A. At each observation point, no significant difference was found between group C and group D.5.Substance P: Since the7days after modeling, the level of substance P of group C and D was significantly lower than group B(p<0.05), but always higher than group A. At each observation point, no significant difference was found between group C and group D.6.The tibia Ca2+average density testing: At twenty-one days after the modeling, the distal Ca2+average density of the right tibia of group B is significantly lower than group A(p<0.05). No significant difference was found in other groups.Conclusion:1.Ischemia reperfusion model can simulate the pathophysiological process of CRPS, and modeling process is easy to operate.2.Since the7days after modeling, nandrolone phenylpropionate can signifi-cantlyimprove pain behavior index of the experimental animal, and reduce the expression of substance P.3.Nandrolone phenylpropionate can increase the local Ca2+average density and muscle strength of experimental animal, and prevent the development of CRPS. [U][B]In summary, the study shows that nandrolone phenylpropionate has a good effect on CRPS with the rat model. So the clinical efficacy of nandrolone phenylpropionate is worthy of further experimental study. [/B][/U] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone for CRPS/RSD
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