My TRT Odyssey: Lab Results and More

If you're looking to preserve GnRH signaling in the presence of exogenous testosterone then you're pretty much limited to testosterone nasal gel, e.g. Natesto, or the combination of oral testosterone and enclomiphene. Alternatives are either less practical — e.g. injecting exogenous GnRH (gonadorelin) several times daily — or speculative — e.g. adding cistanche extract and enclomiphene to a conventional TRT protocol.


Plausible, though for me adding GnRH to TRT led to a much greater improvement than when adding hCG. LH is a pulsatile hormone, so I feel that SC/IM hCG is an imperfect replacement.

I'm not familiar with cistanche, would it be necessary for adding enclo to TRT?

And when you say adding GnRH led to an improvement, are you referring specifically to cognitive function? Did you get GnRH prescribed by a doctor and if so, how?
 
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I'm not familiar with cistanche, would it be necessary for adding enclo to TRT?

And when you say adding GnRH led to an improvement, are you referring specifically to cognitive function? Did you get GnRH prescribed by a doctor and if so, how?
Here's the post where I speculate about a cistanche/enclomiphene combination. For most guys an appropriate SARM is necessary to make enclomiphene effective with conventional TRT. I don't know if cistanche is such a SARM.

GnRH led to improvements in both cognition and libido. Gonadorelin can be obtained from Hallandale Pharmacy with a prescription, or as a research chemical from Peptide Sciences.
 
Here's the post where I speculate about a cistanche/enclomiphene combination. For most guys an appropriate SARM is necessary to make enclomiphene effective with conventional TRT. I don't know if cistanche is such a SARM.

GnRH led to improvements in both cognition and libido. Gonadorelin can be obtained from Hallandale Pharmacy with a prescription, or as a research chemical from Peptide Sciences.
Have you ever tried or speculated about the use of the usual RC SARMs such as LGD or osterine? Not sure what the long term effects of low dose use would be, I don't see any medical grade SARMs out there though.
 
Have you ever tried or speculated about the use of the usual RC SARMs such as LGD or osterine? Not sure what the long term effects of low dose use would be, I don't see any medical grade SARMs out there though.
As far as I know these SARMs are not antagonistic of androgen receptors in the hypothalamus, which makes them either neutral or suppressive with respect to the HPTA.
 

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HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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