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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My friends response to testosterone prop, how is this even possible?
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<blockquote data-quote="Cataceous" data-source="post: 150070" data-attributes="member: 38109"><p>In theory this represents what serum testosterone would look like each day if the particular individual were taking that dose daily. The single-dose response curve for the second individual in the study did not look dramatically different, so I would dispute that this result is "hooey". What it suggests is that there's fairly little variation with daily propionate, which is disappointing if we're trying to approximate a diurnal rhythm.</p><p></p><p>Recall that I started <a href="https://www.excelmale.com/forum/threads/does-shbg-affect-the-apparent-half-lives-of-testosterone-esters.17857/" target="_blank">a thread</a> in which we discussed the high likelihood that SHBG has little-to-no effect on the apparent half-life of testosterone esters. The same would apply to other individual factors affecting the metabolic clearance rate of testosterone.</p><p></p><p>I suppose it is possible that there are other individual factors affecting half-lives of testosterone esters via effects on depot absorption, but if so they have not been characterized that I know of. One way to get a sense of the magnitude of this effect would be to look at the standard deviation for apparent half-lives in studies involving many individuals.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 150070, member: 38109"] In theory this represents what serum testosterone would look like each day if the particular individual were taking that dose daily. The single-dose response curve for the second individual in the study did not look dramatically different, so I would dispute that this result is "hooey". What it suggests is that there's fairly little variation with daily propionate, which is disappointing if we're trying to approximate a diurnal rhythm. Recall that I started [URL='https://www.excelmale.com/forum/threads/does-shbg-affect-the-apparent-half-lives-of-testosterone-esters.17857/']a thread[/URL] in which we discussed the high likelihood that SHBG has little-to-no effect on the apparent half-life of testosterone esters. The same would apply to other individual factors affecting the metabolic clearance rate of testosterone. I suppose it is possible that there are other individual factors affecting half-lives of testosterone esters via effects on depot absorption, but if so they have not been characterized that I know of. One way to get a sense of the magnitude of this effect would be to look at the standard deviation for apparent half-lives in studies involving many individuals. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My friends response to testosterone prop, how is this even possible?
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