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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
My E2 is sky High pls HELP .
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<blockquote data-quote="sbstrum_MD" data-source="post: 256802" data-attributes="member: 17682"><p>I am a hematologist/oncologist that has specialized in prostate cancer since 1983. Most often lay websites have a lot of nonsense posted. But I will say that many of the comments on Excelmate are of high quality and I am pleasantly surprised to see some of the comments that are trying to steer you in the right direction. However, I see your replies and the protests within. Yes, Sammmy is right. You have overdosed your testosterone dose and with it you have up-regulated aromatization of T ⇢ Estradiol (E2). And with the ↑ in E2 you have stimulated prolactin and that is not good for reasons in the list below:</p><p>Prolactin actions: </p><p>1) acts synergistically with LH to stimulate testosterone secretion from testicles by increasing the number of LH receptors in the testis; </p><p>2) influences adrenal androgen formation; </p><p>3) enhances testosterone uptake by prostatic cells; </p><p>4) alters intra-prostatic androgen metabolism</p><p>5) increases uPA to dissolve ECM (extracellular matrix) and facilitate spread of CA</p><p>6) enhances angiogenesis</p><p>7) decreases libido</p><p>8) decreases cognitive function </p><p></p><p>Sammmy's recommendation to use an Aromatase Inhibitor like exemestane (Aromasin®) is perfectly reasonable but he correctly points out that the preceding culprit (the chicken and not the egg) is the overdose of testosterone. </p><p></p><p>With an ↑ E2 and also a higher than normal hematocrit (HCT), you put yourself at risk for thrombosis (i.e., deep vein thrombosis, pulmonary embolism, myocardial infarction). Then all your plans for having a child in the future are kaput. Take the lead from many on this forum to lower your exogenous testosterone dose. Then follow-up with labs. If your free testosterone is in the target range but your E2 is still high then lower it with Aromasin or anastrozole (Arimidex®). Most men I treat with Arimidex only require 0.5 mg twice a week but the proof of the pudding so to speak, is in the follow-up labs documenting success. The key word in most of your woes is "titration." Titration is the essence of biofeedback used intelligently. </p><p>Stephen B. Strum, MD, FACP</p></blockquote><p></p>
[QUOTE="sbstrum_MD, post: 256802, member: 17682"] I am a hematologist/oncologist that has specialized in prostate cancer since 1983. Most often lay websites have a lot of nonsense posted. But I will say that many of the comments on Excelmate are of high quality and I am pleasantly surprised to see some of the comments that are trying to steer you in the right direction. However, I see your replies and the protests within. Yes, Sammmy is right. You have overdosed your testosterone dose and with it you have up-regulated aromatization of T ⇢ Estradiol (E2). And with the ↑ in E2 you have stimulated prolactin and that is not good for reasons in the list below: Prolactin actions: 1) acts synergistically with LH to stimulate testosterone secretion from testicles by increasing the number of LH receptors in the testis; 2) influences adrenal androgen formation; 3) enhances testosterone uptake by prostatic cells; 4) alters intra-prostatic androgen metabolism 5) increases uPA to dissolve ECM (extracellular matrix) and facilitate spread of CA 6) enhances angiogenesis 7) decreases libido 8) decreases cognitive function Sammmy's recommendation to use an Aromatase Inhibitor like exemestane (Aromasin®) is perfectly reasonable but he correctly points out that the preceding culprit (the chicken and not the egg) is the overdose of testosterone. With an ↑ E2 and also a higher than normal hematocrit (HCT), you put yourself at risk for thrombosis (i.e., deep vein thrombosis, pulmonary embolism, myocardial infarction). Then all your plans for having a child in the future are kaput. Take the lead from many on this forum to lower your exogenous testosterone dose. Then follow-up with labs. If your free testosterone is in the target range but your E2 is still high then lower it with Aromasin or anastrozole (Arimidex®). Most men I treat with Arimidex only require 0.5 mg twice a week but the proof of the pudding so to speak, is in the follow-up labs documenting success. The key word in most of your woes is "titration." Titration is the essence of biofeedback used intelligently. Stephen B. Strum, MD, FACP [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
My E2 is sky High pls HELP .
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