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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My daily Testosterone Propionate diary
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<blockquote data-quote="Cataceous" data-source="post: 155160" data-attributes="member: 38109"><p>Once again: there's no evidence for this and no plausible mechanism for SHBG to set the serum half-life, which is implied by the terms "faster" and "longer". Instead, think "larger" and "smaller". The high SHBG guy has higher total testosterone for the same dose, while the low SHBG guy has lower total testosterone. Repeating an earlier illustration: take a guy with high SHBG on TRT, with peak serum testosterone of 1,000 ng/dL and trough of 500. Suddenly, drop his SHBG and change nothing else. What happens? Answer: both peak and trough levels drop in proportion, e.g. to 500 and 250 respectively. Critically, free testosterone remains the same, because it's controlled by the TRT dose, which doesn't change.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 155160, member: 38109"] Once again: there's no evidence for this and no plausible mechanism for SHBG to set the serum half-life, which is implied by the terms "faster" and "longer". Instead, think "larger" and "smaller". The high SHBG guy has higher total testosterone for the same dose, while the low SHBG guy has lower total testosterone. Repeating an earlier illustration: take a guy with high SHBG on TRT, with peak serum testosterone of 1,000 ng/dL and trough of 500. Suddenly, drop his SHBG and change nothing else. What happens? Answer: both peak and trough levels drop in proportion, e.g. to 500 and 250 respectively. Critically, free testosterone remains the same, because it's controlled by the TRT dose, which doesn't change. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My daily Testosterone Propionate diary
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