MSM (Methylsulfonylmethane): A Supplement with Many Benefits

[Nelson Vergel]

Methylsulfonylmethane (Dimethylsulfone or, more commonly, MSM) is a small DMSO-related sulfur-containing molecule used for its antioxidative and anti-inflammatory properties. It holds potential for joint health (not significantly different than glucosamine sulfate).

MSM, a muscle enhancer that sabotages cancer cells
According to in vitro studies, MSM blocks the demolition hormone cortisol in muscle cells while increasing the action of IGF-1 and growth hormone. With such beautiful muscle strengthening effects, we get worried that MSM may also promote cancer.
https://www.ergo-log.com/msm-a-muscle-enhancer-that-sabotages-cancer-cells.html

MSM, growth hormone and IGF-1 | Stronger bones, stronger muscles?
MSM may enhance the action of growth hormone and IGF-1 in muscle tissue, we speculate today after reading a spectacular in vitro study.
https://www.ergo-log.com/msm-growth-hormone-igf-1-stronger-bones-stronger-muscles.html

MSM for athletes | MSM is a cortisol blocker
MSM protects muscles during physical exertion, this website has reported several times. Thanks to an in vitro study that Korean researchers at Konkuk University published in Experimental and Therapeutic Medicine, we understand a little better how.
https://www.ergo-log.com/msm-is-a-cortisol-blocker.html

A capsule of MSM per day reduces wrinkles in a few months

MSM, a dirt cheap organic sulfur compound that you can buy at almost any drug store, is a skinceutical. American researchers experimented with people aged 35-69, and found that even with a modest intake of 1 gram of MSM per day, facial wrinkles get smaller and can even disappear completely.

www.ergo-log.com

 

[Nelson Vergel]

J Int Soc Sports Nutr
. 2012 Sep 27;9(1):46. doi: 10.1186/1550-2783-9-46.

Influence of Methylsulfonylmethane on Markers of Exercise Recovery and Performance in Healthy Men: A Pilot Study

Douglas S Kalman 1, Samantha Feldman, Andrew R Scheinberg, Diane R Krieger, Richard J Bloomer


Abstract
Background: Methylsulfonylmethane (MSM) has been reported to provide anti-inflammatory and antioxidant effects in both animal and man. Strenuous resistance exercise has the potential to induce both inflammation and oxidative stress. Using a pilot (proof of concept) study design, we determined the influence of MSM on markers of exercise recovery and performance in healthy men.

Methods: Eight, healthy men (27.1 ± 6.9 yrs old) who were considered to be moderately exercise-trained (exercising <150 minutes per week) were randomly assigned to ingest MSM at either 1.5 grams per day or 3.0 grams per day for 30 days (28 days before and 2 days following exercise). Before and after the 28 day intervention period, subjects performed 18 sets of knee extension exercise in an attempt to induce muscle damage (and to be used partly as a measure of exercise performance). Sets 1-15 were performed at a predetermined weight for 10 repetitions each, while sets 16-18 were performed to muscular failure. Muscle soreness (using a 5-point Likert scale), fatigue (using the fatigue-inertia subset of the Profile of Mood States), blood antioxidant status (glutathione and Trolox Equivalent Antioxidant Capacity [TEAC]), and blood homocysteine were measured before and after exercise, pre and post intervention. Exercise performance (total work performed during sets 16-18 of knee extension testing) was also measured pre and post intervention.

Results: Muscle soreness increased following exercise and a trend was noted for a reduction in muscle soreness with 3.0 grams versus 1.5 grams of MSM (p = 0.080), with a 1.0 point difference between dosages. Fatigue was slightly reduced with MSM (p = 0.073 with 3.0 grams; p = 0.087 for both dosages combined). TEAC increased significantly following exercise with 3.0 grams of MSM (p = 0.035), while homocysteine decreased following exercise for both dosages combined (p = 0.007). No significant effects were noted for glutathione or total work performed during knee extension testing (p > 0.05).

Conclusion: MSM, especially when provided at 3.0 grams per day, may favorably influence selected markers of exercise recovery. More work is needed to extend these findings, in particular using a larger sample of subjects and the inclusion of additional markers of exercise recovery and performance.

 

[Fernando Almaguer]

where can we get some Nelson?

 

[Vince]

There are various devotees of MSM. Some claim miraculous benefits.
There are a few sulfur Guru’s who think it does EVERYTHING.
I remember David Wolf liked MSM.

I’ve tried it for several years, but am not on it now.
Yeah, it’s OK. I don’t have an joint pain now, so who knows.

I was using this brand

Or a better way is just to eat a lot of garlic, onions, and eggs.

 

[Nelson Vergel]

I use this one (OptiMSM are the patent holders):

Amazon.com

 

[fifty]

Good substance but watch out for gas #methaneman. I took msm for years back in the early 2000s.

 

[Nelson Vergel]

I do not get gas but sometimes I bloat a little. I only take it when I have body and joint aches. It works after a few days.

 

[TucsonJJ]

J Int Soc Sports Nutr
. 2012 Sep 27;9(1):46. doi: 10.1186/1550-2783-9-46.

Influence of Methylsulfonylmethane on Markers of Exercise Recovery and Performance in Healthy Men: A Pilot Study

Douglas S Kalman 1, Samantha Feldman, Andrew R Scheinberg, Diane R Krieger, Richard J Bloomer


Abstract
Background: Methylsulfonylmethane (MSM) has been reported to provide anti-inflammatory and antioxidant effects in both animal and man. Strenuous resistance exercise has the potential to induce both inflammation and oxidative stress. Using a pilot (proof of concept) study design, we determined the influence of MSM on markers of exercise recovery and performance in healthy men.

Methods: Eight, healthy men (27.1 ± 6.9 yrs old) who were considered to be moderately exercise-trained (exercising <150 minutes per week) were randomly assigned to ingest MSM at either 1.5 grams per day or 3.0 grams per day for 30 days (28 days before and 2 days following exercise). Before and after the 28 day intervention period, subjects performed 18 sets of knee extension exercise in an attempt to induce muscle damage (and to be used partly as a measure of exercise performance). Sets 1-15 were performed at a predetermined weight for 10 repetitions each, while sets 16-18 were performed to muscular failure. Muscle soreness (using a 5-point Likert scale), fatigue (using the fatigue-inertia subset of the Profile of Mood States), blood antioxidant status (glutathione and Trolox Equivalent Antioxidant Capacity [TEAC]), and blood homocysteine were measured before and after exercise, pre and post intervention. Exercise performance (total work performed during sets 16-18 of knee extension testing) was also measured pre and post intervention.

Results: Muscle soreness increased following exercise and a trend was noted for a reduction in muscle soreness with 3.0 grams versus 1.5 grams of MSM (p = 0.080), with a 1.0 point difference between dosages. Fatigue was slightly reduced with MSM (p = 0.073 with 3.0 grams; p = 0.087 for both dosages combined). TEAC increased significantly following exercise with 3.0 grams of MSM (p = 0.035), while homocysteine decreased following exercise for both dosages combined (p = 0.007). No significant effects were noted for glutathione or total work performed during knee extension testing (p > 0.05).

Conclusion: MSM, especially when provided at 3.0 grams per day, may favorably influence selected markers of exercise recovery. More work is needed to extend these findings, in particular using a larger sample of subjects and the inclusion of additional markers of exercise recovery and performance.

DMSO has been reported to have the same and many more benefits... any reason you choose to go with MSM vs DMSO? Smell? I read that DMSO eye drops can sometimes reverse macular degeneration and floaters... but would think that if so... we all would have heard of it... MANY other benefits alleged... but for sure is not "mainstream"...

 

[Nelson Vergel]

DMSO smells and MSM is relatively cheap.