Mobility and Biomechanical Functions in the Aging Male: Testosterone and the Locomotive Syndrome

madman

Super Moderator
Conclusion

The progress of modern medicine has led to a major extension in life expectation. However, the quality of life in the elderly largely depends on the extent of their mobility and the ability to live without external help. However, even though organs are healthy, the supporting structure composed of bones, muscles, nerves, joints, intervertebral disks, and blood vessels tend to weaken with increasing age. If one of the structures above does not function properly, the locomotive abilities can be severely impaired, resulting in an increase of morbidity and mortality in the aging population. Despite the existence of pharmaceutical medications for each of those conditions, they often do not cure the disease but only temporarily treat it. On the other hand, testosterone declines with age leading to the downregulation of pathways involved in many aspects of the locomotive syndrome. Therefore, testosterone replacement therapy might be a holistic treatment for each of the mentioned locomotive symptoms.
 

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