Mixed Results from Testosterone Therapy Study

Dr. Morganthaler gives his opinion on the recent studies published in JAMA in this editorial.

While the improvements observed in bone density and anemia were not surprising in light of prior research, these results in carefully performed controlled studies sponsored by the National Institutes of Health provide a clear rationale for the clinical application of TTh for general medical indications, and not just for sexual symptoms. In addition, the weight of evidence presented in these studies is not only reassuring with regard to CV risk, but actually supports the idea that TTh may be cardioprotective. These findings support the call to investigate the possible CV benefits of TTh made by the International Expert Consensus Conference on Testosterone Deficiency and its Treatment in 2016. Urologists already play a central role in the evaluation and management of men with T deficiency. These new, exciting results provide even more evidence to support the importance of normal T values to men's health.
 

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HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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