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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Metformin Reduces Muscle Growth from Resistance Training
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<blockquote data-quote="Jinzang" data-source="post: 159686" data-attributes="member: 12925"><p>A new blinded study found that metformin reduces muscle growth from resistance training. A cautionary note to those taking it for anti-aging purposes. The <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13039" target="_blank">full text of the study</a> is available at the link.</p><p></p><p>Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would augment the muscle response to PRT in healthy women and men aged 65 and older. In a randomized, double‐blind trial, participants received 1,700 mg/day metformin (<em>N</em> = 46) or placebo (<em>N</em> = 48) throughout the study, and all subjects performed 14 weeks of supervised PRT. Although responses to PRT varied, placebo gained more lean body mass (<em>p</em> = .003) and thigh muscle mass (<em>p</em> < .001) than metformin. CT scan showed that increases in thigh muscle area (<em>p</em> = .005) and density (<em>p</em> = .020) were greater in placebo versus metformin. There was a trend for blunted strength gains in metformin that did not reach statistical significance. Analyses of vastus lateralis muscle biopsies showed that metformin did not affect fiber hypertrophy, or increases in satellite cell or macrophage abundance with PRT. However, placebo had decreased type I fiber percentage while metformin did not (<em>p</em> = .007).</p></blockquote><p></p>
[QUOTE="Jinzang, post: 159686, member: 12925"] A new blinded study found that metformin reduces muscle growth from resistance training. A cautionary note to those taking it for anti-aging purposes. The [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13039']full text of the study[/URL] is available at the link. Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would augment the muscle response to PRT in healthy women and men aged 65 and older. In a randomized, double‐blind trial, participants received 1,700 mg/day metformin ([I]N[/I] = 46) or placebo ([I]N[/I] = 48) throughout the study, and all subjects performed 14 weeks of supervised PRT. Although responses to PRT varied, placebo gained more lean body mass ([I]p[/I] = .003) and thigh muscle mass ([I]p[/I] < .001) than metformin. CT scan showed that increases in thigh muscle area ([I]p[/I] = .005) and density ([I]p[/I] = .020) were greater in placebo versus metformin. There was a trend for blunted strength gains in metformin that did not reach statistical significance. Analyses of vastus lateralis muscle biopsies showed that metformin did not affect fiber hypertrophy, or increases in satellite cell or macrophage abundance with PRT. However, placebo had decreased type I fiber percentage while metformin did not ([I]p[/I] = .007). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Metformin Reduces Muscle Growth from Resistance Training
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