madman
Super Moderator
CONCLUSION
After half a century, metformin has established itself as a first defense against insulin-dependent morbidities and undoubtedly has become a useful drug for improving fertility outcomes in both male and female patients.Metformin can modify testis and ovary function directly through AMPK-dependent and independent mechanisms. Its effects include improved sperm function and fertilization rates, oocyte quality and embryo development and reduction in miscarriage rates. The general consensus in the literature is that metformin is considered safe to use during pregnancy in regards to perinatal outcomes. However, adverse effects of metformin in the germ cell populations of offsprings exposed in utero and those on subsequent generations are less clear. While our understanding of the effects of metformin is continually progressing ,further research is needed to have a more complete understanding of metformin’s impact on fertility
After half a century, metformin has established itself as a first defense against insulin-dependent morbidities and undoubtedly has become a useful drug for improving fertility outcomes in both male and female patients.Metformin can modify testis and ovary function directly through AMPK-dependent and independent mechanisms. Its effects include improved sperm function and fertilization rates, oocyte quality and embryo development and reduction in miscarriage rates. The general consensus in the literature is that metformin is considered safe to use during pregnancy in regards to perinatal outcomes. However, adverse effects of metformin in the germ cell populations of offsprings exposed in utero and those on subsequent generations are less clear. While our understanding of the effects of metformin is continually progressing ,further research is needed to have a more complete understanding of metformin’s impact on fertility
