I use a brand called Charlotte's Web, and use liquid. One, eye dropper in the morning, one, evening. I have virtually eliminated the need for nsaids, which I needed 2 to 3 times per week. I took 2 ibuprofen in the last month, only because I was getting a migraine. No downside or impact on hormones. THC would maybe, but *** has no THC and is not psychoactive. No high.