ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Male Hypogonadism- Low Testosterone: Treatment Choices
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 191276" data-attributes="member: 13851"><p><strong>hCG </strong></p><p></p><p><em><span style="color: rgb(184, 49, 47)">hCG is a glycoprotein produced by placental trophoblastic cells starting from the 10th-12th embryonic day, and it is required for the maintenance of the fetus in the first trimester. </span><span style="color: rgb(44, 130, 201)"><strong><u>The β-subunit of hCG shares with that of LH 82% amino acid homology</u>.31</strong></span></em> <em><span style="color: rgb(184, 49, 47)">On this basis, hCG extracted from the urine of pregnant women or produced in vitro using recombinant DNA technology is currently used for the treatment of central hypogonadism.32 </span></em><strong><span style="color: rgb(44, 130, 201)"><em><u>It enhances T synthesis by stimulating Leydig cell function</u>.</em></span></strong> <span style="color: rgb(26, 188, 156)"><strong><em><u>hCG, administered by IM or subcutaneous injection, has a biological halflife of 8 hours</u></em></strong><em><strong>.</strong></em></span><strong><span style="color: rgb(44, 130, 201)"><em> <u>On the other hand, due to the above-mentioned chemical differences with LH, the latter has a half-life of only 30 minutes and, therefore, it is not used in clinical practice</u>.</em></span></strong> <span style="color: rgb(184, 49, 47)"><em>Doses of hCG ranging from 2000 IU twice/week in patients with LOH33 to 1500-2000 IU three times/week in patients with central hypogonadism34, 35 have been successfully used to raise T levels for up to 24 months.35</em></span><span style="color: rgb(44, 130, 201)"><em><strong> <u>One of the advantages of hCG administration is the increase of intra-tubular T levels, which, on the opposite, are suppressed in patients on TRT</u>. </strong></em></span><span style="color: rgb(26, 188, 156)"><em><strong><u>The raise of intra-tubular T levels is better accomplished using low-dose schemes (125 IU every other day)36 and it is crucial to sustaining spermatogenesis</u>.</strong></em></span><span style="color: rgb(184, 49, 47)"><em> However, hCG at high doses has been also found compatible with the achievement of spontaneous pregnancy.35 Indeed, among 20 patients with central hypogonadism treated with 1500-2000 IU three times a week, 10 searched paternities and 7 of them achieved it naturally.35</em></span><span style="color: rgb(26, 188, 156)"><em> <strong><u>Accordingly, hCG has been shown to stimulate the recovery of spermatogenesis in patients with central hypogonadism who have been treated with TRT</u>.37 </strong></em></span><span style="color: rgb(184, 49, 47)"><em>Treatment with hCG has been also observed to increase vitamin D levels. However, this topic requires further investigation since only few evidence is available so far.33, 38, 39 </em></span></p></blockquote><p></p>
[QUOTE="madman, post: 191276, member: 13851"] [B]hCG [/B] [I][COLOR=rgb(184, 49, 47)]hCG is a glycoprotein produced by placental trophoblastic cells starting from the 10th-12th embryonic day, and it is required for the maintenance of the fetus in the first trimester. [/COLOR][COLOR=rgb(44, 130, 201)][B][U]The β-subunit of hCG shares with that of LH 82% amino acid homology[/U].31[/B][/COLOR][/I] [I][COLOR=rgb(184, 49, 47)]On this basis, hCG extracted from the urine of pregnant women or produced in vitro using recombinant DNA technology is currently used for the treatment of central hypogonadism.32 [/COLOR][/I][B][COLOR=rgb(44, 130, 201)][I][U]It enhances T synthesis by stimulating Leydig cell function[/U].[/I][/COLOR][/B][COLOR=rgb(251, 160, 38)][I][B] [/B][/I][/COLOR][COLOR=rgb(26, 188, 156)][B][I][U]hCG, administered by IM or subcutaneous injection, has a biological halflife of 8 hours[/U][/I][/B][I][B].[/B][/I][/COLOR][B][COLOR=rgb(44, 130, 201)][I] [U]On the other hand, due to the above-mentioned chemical differences with LH, the latter has a half-life of only 30 minutes and, therefore, it is not used in clinical practice[/U].[/I][/COLOR][/B] [COLOR=rgb(184, 49, 47)][I]Doses of hCG ranging from 2000 IU twice/week in patients with LOH33 to 1500-2000 IU three times/week in patients with central hypogonadism34, 35 have been successfully used to raise T levels for up to 24 months.35[/I][/COLOR][COLOR=rgb(44, 130, 201)][I][B] [U]One of the advantages of hCG administration is the increase of intra-tubular T levels, which, on the opposite, are suppressed in patients on TRT[/U]. [/B][/I][/COLOR][COLOR=rgb(26, 188, 156)][I][B][U]The raise of intra-tubular T levels is better accomplished using low-dose schemes (125 IU every other day)36 and it is crucial to sustaining spermatogenesis[/U].[/B][/I][/COLOR][COLOR=rgb(184, 49, 47)][I] However, hCG at high doses has been also found compatible with the achievement of spontaneous pregnancy.35 Indeed, among 20 patients with central hypogonadism treated with 1500-2000 IU three times a week, 10 searched paternities and 7 of them achieved it naturally.35[/I][/COLOR][COLOR=rgb(26, 188, 156)][I] [B][U]Accordingly, hCG has been shown to stimulate the recovery of spermatogenesis in patients with central hypogonadism who have been treated with TRT[/U].37 [/B][/I][/COLOR][COLOR=rgb(184, 49, 47)][I]Treatment with hCG has been also observed to increase vitamin D levels. However, this topic requires further investigation since only few evidence is available so far.33, 38, 39 [/I][/COLOR] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Male Hypogonadism- Low Testosterone: Treatment Choices
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top