Major Depressive Disorder: Next-Generation Neurosteroids

madman

Super Moderator
PPD: Postpartum depression
MDD: Major Depressive Disorder





This webcast features presentations that examine the diverse pathophysiologic mechanisms that may contribute to MDD and PPD and the resultant implications for therapeutic targeting, including the GABAergic signaling pathway.


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"
Brinton and her colleagues found evidence that allopregnanolone also improves mitochondrial function, redressing the “bioenergetic crisis of AD. We also think it reduces the hallmark pathologies of AD—beta amyloid deposition and phosphorylation of tau.”

Neuroinflammation is another pathophysiological mechanism in AD`, and she noted that allopregnanolone “is a very effective anti-inflammatory drug.”

Given their multiple modes of action, a role for neurosteroids in other neurodegenerative disorders seems worth pursuing, she says. “Thus far, we only have preclinical evidence in a Parkinson’s model; allopregnanolone promotes regeneration of dopaminergic fibers [which are vastly depleted in Parkinson’s]. We have to pursue that more deeply. We’re focusing on common mechanisms across age-related neurodegenerative diseases; we know, for example, that there is a bioenergetic crisis in Parkinson’s, ALS (amyotrophic lateral sclerosis), and multiple sclerosis, as well as AD. There’s also evidence allopregnanolone promotes the regeneration of white matter,” the nerve fibers that connect brain regions."



 
I found a research chem site that claims to be selling allopregnanolone. What are the odds this is legitimate ?
The hardest part of trying anything is that there is no commercially (consumer) test available for allopregnanolone. There is only testing available for research.
 

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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