Major Depressive Disorder: Next-Generation Neurosteroids

[madman]

PPD: Postpartum depression
MDD: Major Depressive Disorder

This webcast features presentations that examine the diverse pathophysiologic mechanisms that may contribute to MDD and PPD and the resultant implications for therapeutic targeting, including the GABAergic signaling pathway.

 

[madman]

 

[madman]

 

[madman]

 

[madman]

 

[madman]

Development of neuroactive steroids for the treatment of postpartum depression - Excel Male TRT Forum

Abstract Postpartum depression (PPD) is a common major depressive episode surrounding childbirth, with estimated rates ranging from 5.5% to 23.5% of all live births across Europe and the USA based on the presence of key symptoms. PPD has been associated with significant impairments in both...

www.excelmale.com

 

[Nelson Vergel]

Damn @madman !!! You are a science magnet machine. Most doctors don't get to see data that we get to see because of you!.

 

[Nelson Vergel]

Allopregnanolone and psychedelic products will change the way psychiatry is practiced forever in less than 5 years.

 

[Nelson Vergel]

Allopregnanolone: An overview on its synthesis and effects - Excel Male TRT Forum

Abstract Allopregnanolone, a 3α,5α-progesterone metabolite, acts as a potent allosteric modulator of the γ-aminobutyric acid type A receptor. In the present review, the synthesis of this neuroactive steroid occurring in the nervous system is discussed with respect to physiological and...

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How Can I Increase My Allopregnanolone ? - Excel Male TRT Forum

We know that pregnenolone and progesterone increase allopregnanolone. Do you know any other hormones that increase allopregnanolone? Strategies to Increase Allopregnanolone for Mental Health Support Introduction: Allopregnanolone, Mood, and TRT Context Allopregnanolone is a naturally...

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Allopregnanolone in mood disorders - Excel Male TRT Forum

ABSTRACT The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric modulator of GABA type A receptor (GABAAR), and the down-regulation of its biosynthesis has been attributed to the development of mood disorders, such as depression, anxiety, and post-traumatic stress...

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Allopregnanolone and neuroHIV - Excel Male TRT Forum

Abstract Forty years into the HIV pandemic, approximately 50% of infected individuals still suffer from a constellation of neurological disorders collectively known as ‘neuroHIV.’ Although combination antiretroviral therapy (cART) has been a tremendous success, in its present form, it cannot...

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TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety? - Excel Male TRT Forum

In this video dr Mark Gordon, starting at 9min, explains how using good level of TRT can "burn" 5 alpha reductase enzyme, that beside being responsible for converting Test into DHT, it is also responsible for converting Progesterone into Allopregnanolone in the brain. Throughout the...

www.excelmale.com

 

[Nelson Vergel]

Frontiers | Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next?

Allopregnanolone, today best known as brexanolone and marketed as Zulresso for the treatment of postpartum depression is now part of only two recently US Foo...

www.frontiersin.org

 

[Nelson Vergel]

"
Brinton and her colleagues found evidence that allopregnanolone also improves mitochondrial function, redressing the “bioenergetic crisis of AD. We also think it reduces the hallmark pathologies of AD—beta amyloid deposition and phosphorylation of tau.”

Neuroinflammation is another pathophysiological mechanism in AD`, and she noted that allopregnanolone “is a very effective anti-inflammatory drug.”

Given their multiple modes of action, a role for neurosteroids in other neurodegenerative disorders seems worth pursuing, she says. “Thus far, we only have preclinical evidence in a Parkinson’s model; allopregnanolone promotes regeneration of dopaminergic fibers [which are vastly depleted in Parkinson’s]. We have to pursue that more deeply. We’re focusing on common mechanisms across age-related neurodegenerative diseases; we know, for example, that there is a bioenergetic crisis in Parkinson’s, ALS (amyotrophic lateral sclerosis), and multiple sclerosis, as well as AD. There’s also evidence allopregnanolone promotes the regeneration of white matter,” the nerve fibers that connect brain regions."

Neurosteroids: A Major Step Forward

Research that began three-quarters of a century ago has led to one of the first new drugs to treat depression in 60 years—and the potential to treat much more.

www.dana.org

 

[Graham]

I found a research chem site that claims to be selling allopregnanolone. What are the odds this is legitimate ?

 

[Nelson Vergel]

I found a research chem site that claims to be selling allopregnanolone. What are the odds this is legitimate ?

The hardest part of trying anything is that there is no commercially (consumer) test available for allopregnanolone. There is only testing available for research.