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I'm not sure I have enough data to say anything definitive. My estradiol measurements were more consistent with frequent injections of enanthate, such that, for example, I could say with reasonable certainty that hCG use increases the E2/T ratio. However, with a propionate blend the measurements are more variable. There's some indication that estradiol lags testosterone, such that E2/T is generally smaller at peak serum testosterone than at the trough. My highest recorded E2/T, >1%, occurred at trough on a propionate-only protocol.