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does not seem to be KNOWN why it happens, just that it does, although there are theories. anyway, again, i think its important to understand things but perhaps your over intellectualizing something that no one here REALLY knows ie full endocrine system is ULTRA complex and we pretend we get it and control it with the very few tools we have.


if get it checked when feel bad and when feel good and see difference.


also keep in mind testosterone can mask ALOT of things from mental illness to physical maladies.  just like someone who takes opiates may feel horrible day after they take an opiate and that only gets worse the longer that take it may get sensitive to pain etc. when injecting an ester often the likelihood of HUGE variance in either testosterone or E is less likely, we are talking about multi day half lives and infact it possible could be the PEAK testosterone actually causing the issue but of course may be many things at once not T or E themselves..


and like opiates Testosterone plays a roll in dopamine and sleep aswell, so possible your having withdrawal type symptoms...


anyway, just offering something folks far more knowledgeable and experienced than me have said... "many guys think they have high E symptoms but its prolactin".  so may be something to test and see. discussing how or why wont help as none of us are endos.



anyway, let us know when get bloods as will be interesting to see the E and prolactin and test levels!


hows ur other bloodwork like ferritin and iron and CBC?


also possible is cortisol levels...


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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