ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG: T Gel along with Injected T has Helped Somewhat
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Dr Justin Saya MD" data-source="post: 73255" data-attributes="member: 12687"><p>Copying here one of my responses from a thread over on PeakT regarding low SHBG, which is a topic of interest to me similar to post-finasteride syndrome...as these cases are always notoriously challenging. </p><p></p><p></p><p>"There is clearly more to the story than anyone fully comprehends until more research is dedicated to this area. Certain disease states, as noted, can contribute to a "secondary" low SHBG condition. You also allude to the possibility of a more "primary" low SHBG condition.</p><p></p><p>You may find the following interesting:</p><p></p><p><a href="https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dem382" target="_blank">https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dem382</a></p><p></p><p>Although it is a study of PCOS in females, I have always thought it provided some very thought-provoking data on the genetic components (and variability) when it comes to SHBG and androgen receptors. The study discusses different SHBG alleles and different androgen receptor alleles, these are the genotypes - with certain combinations (in this case long SHBG allele and short AR allele) making the PHENOtype of PCOS more likely...thus pointing to a possible genetic or "fetal programming" as they postulate for developing PCOS. It wouldn't be much of a stretch to imagine the same variables at play for many low SHBG guys (in the absence of the contributing disease states)."</p><p></p><p>Another note - there are some interesting links with female PCOS/genetics as I've had several very low SHBG males with a family history of PCOS in female relatives. Further some of the discussion that board member "James" and I had:</p><p></p><p>"Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome</p><p>Starka L, Duskova M, Cermakova I, Vrbikova J, Hill M.</p><p>Institute of Endocrinology, Narodni 8, CZ 116 94 Prague 1, Czech Republic. </p><p></p><p>Another fascinating study of relevance is one of a man with no detectable SHBG due to a homozygous missense mutation. While the abstract offers little of interest to this discussion, the full case history is much more interesting (although, hard to find for free on the Internet.) As the abstract reveals, he presented with "muscle weakness, fatigue, and a low libido" although he was mostly normal with respect to sexual maturation (as are all of our "Internet" low SHBG cases.) His lack of SHBG caused HTPA suppression and hypogonadism. Testosterone replacement therapy failed to resolve his issues. Also not mentioned in the abstract is that he has a sister with the same condition. The key takeaway being that the complaints related to libido, fatigue and muscle weakness. More importantly, testosterone in the absence of SHBG did not restore libido or strength.</p><p></p><p>Link: <a href="https://www.ncbi.nlm.nih.gov/pubmed/24937543" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/24937543</a></p><p></p><p>Many of the "presumed congenital" cases share the muscle weakness complaint, to the point of claiming to be completely unable to sustain or build noticable mass."</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 73255, member: 12687"] Copying here one of my responses from a thread over on PeakT regarding low SHBG, which is a topic of interest to me similar to post-finasteride syndrome...as these cases are always notoriously challenging. "There is clearly more to the story than anyone fully comprehends until more research is dedicated to this area. Certain disease states, as noted, can contribute to a "secondary" low SHBG condition. You also allude to the possibility of a more "primary" low SHBG condition. You may find the following interesting: [url]https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dem382[/url] Although it is a study of PCOS in females, I have always thought it provided some very thought-provoking data on the genetic components (and variability) when it comes to SHBG and androgen receptors. The study discusses different SHBG alleles and different androgen receptor alleles, these are the genotypes - with certain combinations (in this case long SHBG allele and short AR allele) making the PHENOtype of PCOS more likely...thus pointing to a possible genetic or "fetal programming" as they postulate for developing PCOS. It wouldn't be much of a stretch to imagine the same variables at play for many low SHBG guys (in the absence of the contributing disease states)." Another note - there are some interesting links with female PCOS/genetics as I've had several very low SHBG males with a family history of PCOS in female relatives. Further some of the discussion that board member "James" and I had: "Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome Starka L, Duskova M, Cermakova I, Vrbikova J, Hill M. Institute of Endocrinology, Narodni 8, CZ 116 94 Prague 1, Czech Republic. Another fascinating study of relevance is one of a man with no detectable SHBG due to a homozygous missense mutation. While the abstract offers little of interest to this discussion, the full case history is much more interesting (although, hard to find for free on the Internet.) As the abstract reveals, he presented with "muscle weakness, fatigue, and a low libido" although he was mostly normal with respect to sexual maturation (as are all of our "Internet" low SHBG cases.) His lack of SHBG caused HTPA suppression and hypogonadism. Testosterone replacement therapy failed to resolve his issues. Also not mentioned in the abstract is that he has a sister with the same condition. The key takeaway being that the complaints related to libido, fatigue and muscle weakness. More importantly, testosterone in the absence of SHBG did not restore libido or strength. Link: [url]https://www.ncbi.nlm.nih.gov/pubmed/24937543[/url] Many of the "presumed congenital" cases share the muscle weakness complaint, to the point of claiming to be completely unable to sustain or build noticable mass." [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG: T Gel along with Injected T has Helped Somewhat
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top