Low LH and Elevated DHEAs

Nelson, I just read an excerpt from your book in one of your stickies. Specifically, the following sections regarding reasons for low T:

1. The hypothalamus is not functioning properly. LH levels of less than 2 ng/mL suggest a lesion in this part of the HPGA. .
2. Dehydroepiandrosterone (DHEA) level is abnormally low. DHEA is a hormone produced by the adrenal glands that has a lot of the same benefits as testosterone.

My LH was consistently 1.1 for the past 15 years that I had it checked. I was under the impression it was a pituitary issue but you indicate a hypothalamus lesion. Sounds scary haha. Anything that should be explored or evaluated or treated?

Also, my DHEAs levels have always been either just over the top of range or as high as 5x the upper limit. From your clip it sounds like my t levels should be good or is that an illogical conclusion? Or is that indicative of another issue?


Thanks!!!
 
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I should delete those two confusing statements.

Low LH may mean issues with hypothalamic function (production of hormones, receptor downregulation, etc). Lesion is a strong word that may scare some people.

DHEA does not increase testosterone in men even though it is an androgenic hormones secreted by the adrenal glands. However, it is rare to see men with normal DHEA who have low testosterone blood levels (I am talking about men who are not using TRT)
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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