Low Intensity Pulsed Ultrasound Therapy (LIPUS) on Leydig Cell Function: LIPUS holds potential as a physiologic therapy for hypogonadism

[madman]

This is wild!

Low-intensity Pulsed Ultrasound Enhancement of Testosterone Production

https://patents.justia.com/patent/20230249005

Low-intensity pulsed ultrasound stimulates proliferation of ... : Asian Journal of Andrology

o known adverse reactions. LIPUS has been shown to have many benefits including promotion of tissue healing, angiogenesis, and tissue regeneration; inhibition of inflammation and pain relief; and stimulation of cell proliferation and differentiation. The biophysical mechanisms of LIPUS remain...

journals.lww.com

 

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Biological function of testes

 

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Global expression of human testicular cells from infancy to adulthood by single-cell RNA seq.

 

[madman]

* stem cell therapy based on Leydig cells holds great promise




Background

 

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Adult Stem Leydig Cells Niches: Localization of SLC

 

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Experimental Design

Effects of LIPUS on serum testosterone levels in rats

Effects of LIPUS on serum luteinizing hormone (LH) levels in rats

 

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Effect of LIPUS on Leydig cells in vivo

Regeneration?

 

[madman]

Fascinating!

Testicles: LIPUS treatment

* significantly increases Leydig cell number

 

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Stereological study of Leydig cells post LIPUS therapy

LIPUS therapy increases the number of Leydig cells and testicular blood vessels in older rats

LIPUS activated Wnt and Integrated stress response (ISR) signalling pathway in TM3 Leydig cells in vitro

 

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Summary