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Conversely, extensive studies of the outcome of GH replacement in childhood cancer survivors show no evidence of an excess of de novo cancers, and more recent surveillance of children and adults treated with GH has revealed no increase in observed cancer risk.

[URL unfurl="true"]https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2265.2005.02404.x#:~:text=Conversely%2C%20extensive%20studies%20of%20the%20outcome%20of%20GH,has%20revealed%20no%20increase%20in%20observed%20cancer%20risk.[/URL]

Giovannucci, E., Pollak, M.N., Platz, E.A., Willett, W.C., Stampfer,M.J., Majeed, N., Colditz, G.A., Speizer, F.E. & Hankinson, S.E.(2000) A prospective study of plasma insulin-like growth factor-1and binding protein-3 and risk of colorectal neoplasia in women.Cancer Epidemiology, Biomarkers & Prevention, 9, 345–349.

Conclusions: These results support earlier findings of increased risk of colon cancer in subjects with elevated plasma IGF-1. Our results however do not support the hypothesis that the risk of rectal cancer could also be directly related to IGF-1 levels.
[URL unfurl="true"]https://www.scirp.org/journal/paperinformation.aspx?paperid=81059[/URL]
In conclusion, our study corroborates evidence from previous studies showing that GH replacement therapy in AGHD patients would not increase the risk of cancer; instead, it might be even decrease cancer risk. The results suggested that GH replacement therapy in AGHD patients was safe.

<blockquote data-quote="Deleted member 43589" data-source="post: 266841" data-attributes="member: 43589">Conversely, extensive studies of the outcome of GH replacement in childhood cancer survivors show no evidence of an excess of de novo cancers, and more recent surveillance of children and adults treated with GH has revealed no increase in observed cancer risk.[URL unfurl=&quot;true&quot;]https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2265.2005.02404.x#:~:text=Conversely%2C%20extensive%20studies%20of%20the%20outcome%20of%20GH,has%20revealed%20no%20increase%20in%20observed%20cancer%20risk.[/URL]Giovannucci, E., Pollak, M.N., Platz, E.A., Willett, W.C., Stampfer,M.J., Majeed, N., Colditz, G.A., Speizer, F.E. &amp; Hankinson, S.E.(2000) A prospective study of plasma insulin-like growth factor-1and binding protein-3 and risk of colorectal neoplasia in women.Cancer Epidemiology, Biomarkers &amp; Prevention, 9, 345–349.Conclusions: These results support earlier findings of increased risk of colon cancer in subjects with elevated plasma IGF-1. Our results however do not support the hypothesis that the risk of rectal cancer could also be directly related to IGF-1 levels.[URL unfurl=&quot;true&quot;]https://www.scirp.org/journal/paperinformation.aspx?paperid=81059[/URL]In conclusion, our study corroborates evidence from previous studies showing that GH replacement therapy in AGHD patients would not increase the risk of cancer; instead, it might be even decrease cancer risk. The results suggested that GH replacement therapy in AGHD patients was safe.</blockquote>

[QUOTE="Deleted member 43589, post: 266841, member: 43589"] [I]Conversely, extensive studies of the outcome of GH replacement in childhood cancer survivors show [B]no evidence of an excess of de novo cancers, and more recent surveillance of children and adults treated with GH has revealed no increase in observed cancer risk[/B].[/I] [URL unfurl="true"]https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2265.2005.02404.x#:~:text=Conversely%2C%20extensive%20studies%20of%20the%20outcome%20of%20GH,has%20revealed%20no%20increase%20in%20observed%20cancer%20risk.[/URL] Giovannucci, E., Pollak, M.N., Platz, E.A., Willett, W.C., Stampfer,M.J., Majeed, N., Colditz, G.A., Speizer, F.E. & Hankinson, S.E.(2000) A prospective study of plasma insulin-like growth factor-1and binding protein-3 and risk of colorectal neoplasia in women.Cancer Epidemiology, Biomarkers & Prevention, 9, 345–349. [I]Conclusions: These results support earlier findings of increased risk of colon cancer in subjects with elevated plasma IGF-1. Our results however do not support the hypothesis that the risk of rectal cancer could also be directly related to IGF-1 levels. [URL unfurl="true"]https://www.scirp.org/journal/paperinformation.aspx?paperid=81059[/URL][/I] In conclusion, our study corroborates evidence from previous studies showing that GH replacement therapy in AGHD patients would not increase the risk of cancer; instead, [B]it might be even decrease cancer risk.[/B] The results suggested that GH replacement therapy in AGHD patients was safe. [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038