Life Extension Update on testosterone therapy

  • Thread starter Thread starter Palermitano
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Journal of Cardiovascular Pharmacology and Therapeutics said:
Over a median follow-up period of seven years, only two deaths (neither of which were caused by cardiovascular disease) occurred among those who received testosterone, while 21 deaths, including 19 attributable to cardiovascular disease, occurred among those who were not treated with the hormone, which was equivalent to a 12.4 times greater risk of mortality among untreated subjects. Twenty-six nonfatal heart attacks and 30 nonfatal strokes occurred among subjects who did not receive testosterone, compared to no nonfatal heart attacks and strokes in the testosterone-treated group.
In most drug trials, this would be where they stopped the study to put everyone on testosterone, because not to do that would be completely unethical.

But we're talking about TRT, and TRT ain't cool -- so they shrug and go back to writing scripts for Lipitor.
 
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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