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It´s funny, there are many studies that use 5000iu shots of hcg. monotherapy or in combination with clomid, if i recall one used only hcg 5000iu every two weeks, combined with cialis daily, then one was using 5000 twice per week! Also one study where the average monotherapy dose was 2000iu, seems more reasonable. Has anyone tried the 5000iu bolus, been curious but never had the balls to do it. There is some logic behind doing a very large bolus very infrequently, it could provide a bounceback effect that would carry over to the next one, and maybe there would not be as much desensitization?