I came in with PFS and HCG probably did more for me than test. I’ve had my E2 and T ratio all over and at least for me it does not appear to be that. PFS folks are noted to have lower allopregnenolone levels in the brain and other issues like that, as well as cortisol issues. HCG for me as far as libido and wellbeing go does have an element of what high dose pregnenolone gives me, as if I drop preg my libido goes down. There are also studies showing HCG can increase cortisol secretion, and I do get an element of that from it that seemingly matches what I’ve gotten when playing around with various forms of cortisol. During my issues I also lose the ability to sweat, which things that increase dopamine help, like MOA B inhibitors. HCG has also helped in a similar way.
I’ve tried AI’s before briefly and my libido would initially go up a bit after taking them, so I don’t think it’s having more E2.
Might also be none of that and have more to do with our brains. We really know very little about the on the ground mechanisms of a lot of things.
