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General Health & Fitness
Health & Wellness
Lean mass loss on GLP-1 receptor agonists: a downside of the “miracle drugs”
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<blockquote data-quote="mcs" data-source="post: 246923" data-attributes="member: 12"><p>Has anyone done a DEXA scan before and during use of any GLP-1 agonists (semaglutide, tizepatide) to assess body composition?</p><p></p><p>In Peter Attia's <a href="https://peterattiamd.com/the-downside-of-glp-1-receptor-agonists/" target="_blank">recent blog</a>, he eludes to the fact the GLP-1 agonists can cause loss of lean mass (in addition to fat loss), of particular concern in non-obese persons. The mechanism is simple: reduced appetite = less energy intake over time = both fat and muscle loss.</p><p></p><p>To counter the effects of GLP-1 meds:</p><p></p><p>• <strong>Increase protein consumption via supps (i.e. whey protein. In the face of suppressed appetite, it will be easier to drink protein supplements and whey protein)</strong></p><p><strong>• Hormone optimization to increase protein synthesis (i.e. TRT)</strong></p><p><strong>• Resistance training</strong></p></blockquote><p></p>
[QUOTE="mcs, post: 246923, member: 12"] Has anyone done a DEXA scan before and during use of any GLP-1 agonists (semaglutide, tizepatide) to assess body composition? In Peter Attia's [URL='https://peterattiamd.com/the-downside-of-glp-1-receptor-agonists/']recent blog[/URL], he eludes to the fact the GLP-1 agonists can cause loss of lean mass (in addition to fat loss), of particular concern in non-obese persons. The mechanism is simple: reduced appetite = less energy intake over time = both fat and muscle loss. To counter the effects of GLP-1 meds: • [B]Increase protein consumption via supps (i.e. whey protein. In the face of suppressed appetite, it will be easier to drink protein supplements and whey protein) • Hormone optimization to increase protein synthesis (i.e. TRT) • Resistance training[/B] [/QUOTE]
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General Health & Fitness
Health & Wellness
Lean mass loss on GLP-1 receptor agonists: a downside of the “miracle drugs”
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