ApoE Genotype and Coronary Artery DiseaseAngiographic studies of CHD patients have shown that apo E4 carriers are more often found to have disseminated and severe coronary lesions than noncarriers.[SUP]13[/SUP] The apoE genotype is reported to increase an individual carrier's differential susceptibility to future coronary artery disease (CAD) events. In larger studies and pooled analyses, apo E4 is associated with increased CAD events compared to apo E2 and apo E3. Reported CAD event risk is increased about 40% in apo E4 individuals.[SUP]32[/SUP]
A meta-analysis of clinical events in 6,355 individuals in nine observational studies
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