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ApoE Genotype and Coronary Artery DiseaseAngiographic studies of CHD patients have shown that apo E4 carriers are more often found to have disseminated and severe coronary lesions than noncarriers.[SUP]13[/SUP] The apoE genotype is reported to increase an individual carrier's differential susceptibility to future coronary artery disease (CAD) events. In larger studies and pooled analyses, apo E4 is associated with increased CAD events compared to apo E2 and apo E3. Reported CAD event risk is increased about 40% in apo E4 individuals.[SUP]32[/SUP]
A meta-analysis of clinical events in 6,355 individuals in nine observational studies

http://www.bhlinc.com/clinicians/clinical-references/reference-manual/chapter19

<blockquote data-quote="Vince" data-source="post: 36910" data-attributes="member: 843">ApoE Genotype and Coronary Artery DiseaseAngiographic studies of CHD patients have shown that apo E4 carriers are more often found to have disseminated and severe coronary lesions than noncarriers.[SUP]<a href="http://www.bhlinc.com/clinicians/clinical-references/reference-manual/chapter19#footnote-13" target="_blank">13</a>[/SUP]&nbsp; The apoE genotype is reported to increase an individual carrier&#039;s differential susceptibility to future coronary artery disease (CAD) events.&nbsp; In larger studies and pooled analyses, apo E4 is associated with increased CAD events compared to apo E2 and apo E3.&nbsp; Reported CAD event risk is increased about 40% in apo E4 individuals.[SUP]<a href="http://www.bhlinc.com/clinicians/clinical-references/reference-manual/chapter19#footnote-32" target="_blank">32</a>[/SUP]A meta-analysis of clinical events in 6,355 individuals in nine observational studies <a href="http://www.bhlinc.com/clinicians/clinical-references/reference-manual/chapter19" target="_blank">http://www.bhlinc.com/clinicians/clinical-references/reference-manual/chapter19</a></blockquote>

[QUOTE="Vince, post: 36910, member: 843"] ApoE Genotype and Coronary Artery DiseaseAngiographic studies of CHD patients have shown that apo E4 carriers are more often found to have disseminated and severe coronary lesions than noncarriers.[SUP][URL="http://www.bhlinc.com/clinicians/clinical-references/reference-manual/chapter19#footnote-13"]13[/URL][/SUP] The apoE genotype is reported to increase an individual carrier's differential susceptibility to future coronary artery disease (CAD) events. In larger studies and pooled analyses, apo E4 is associated with increased CAD events compared to apo E2 and apo E3. Reported CAD event risk is increased about 40% in apo E4 individuals.[SUP][URL="http://www.bhlinc.com/clinicians/clinical-references/reference-manual/chapter19#footnote-32"]32[/URL][/SUP] A meta-analysis of clinical events in 6,355 individuals in nine observational studies [URL]http://www.bhlinc.com/clinicians/clinical-references/reference-manual/chapter19[/URL] [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038