IMO 1 cc of aqueous based injectable is no big deal. 27 x 1-1/4 in the glut and I pack 1cc of oil based + 1/2 cc aqueous at one time in the glut. I routinely inject 2 cc of Lipo C ofen with 1/2 cc of hCG.
I may be mistaken but I do not believe pooling occurs with aqueous.