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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Kisspeptin suppression under TRT: Can it affect mood and libido?
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<blockquote data-quote="Cataceous" data-source="post: 249780" data-attributes="member: 38109"><p>You're right, I hadn't read far enough into <a href="https://www.sciencedirect.com/science/article/abs/pii/S1743609515303829" target="_blank">the research</a>. They wrote:</p><p></p><p style="margin-left: 20px"><em>We report here a suppression of IGF-1. This occurs in the absence of any change of SHGB, another liver protein. This indicates a specific suppression rather than a general inhibition of liver function. This suppression of IGF-1 is still within the normal physiologic range which shows an age-related decrease. ...</em></p><p></p><p>But they go on to add:</p><p></p><p style="margin-left: 20px"><em>This observation needs to be confirmed in future studies. If this is due to hGH suppression, we might anticipate a positive effect of serum glucose, given that hGH may be a causative factor for insulin resistance.</em></p><p></p><p>A little more detail in <a href="https://bjui-journals.onlinelibrary.wiley.com/doi/full/10.1111/bju.12363" target="_blank">another piece</a>:</p><p></p><p style="margin-left: 20px"><em>In general, enclomiphene citrate had few changes in these hormones and markers, with the exception of IGF-1. IGF-1 is secreted by the liver and is regulated in part by hGH levels; however circulating levels also are dependent on the proteins that bind IGF-1 in the circulation. IGF-1 levels were decreased in the men in the enclomiphene citrate groups, but not in the transdermal testosterone group, but the levels remained within the normal physiological ranges. We are uncertain as to the significance of this observation. Testosterone treatment of men with testosterone deficiency usually increases serum estradiol levels, and may increase hGH and IGF-1 levels. Estrogen is known to potentiate secretion of hGH and IGF-1 levels. Enclomiphene citrate increases serum estradiol levels. We suspect that the anti-estrogen effects of enclomiphene citrate are working at either the hypothalamic-pituitary level or possibly on the liver to reduce IGF-1 levels. Unfortunately, technical issues prevented the measurement of hGH levels in the serum samples from these men. It would also be relevant to know if enclomiphene citrate treatment affects the IGF-binding proteins.</em></p><p></p><p>I tried to dig into the relationship between estrogens and hGH. I found it to be clear as mud. In any case, I think my overall point holds: there's uncertainty about the effects of long-term enclomiphene use. Influence on IGF-1 by whatever route is still demonstrating less-than-ideal selectivity.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 249780, member: 38109"] You're right, I hadn't read far enough into [URL='https://www.sciencedirect.com/science/article/abs/pii/S1743609515303829']the research[/URL]. They wrote: [INDENT][I]We report here a suppression of IGF-1. This occurs in the absence of any change of SHGB, another liver protein. This indicates a specific suppression rather than a general inhibition of liver function. This suppression of IGF-1 is still within the normal physiologic range which shows an age-related decrease. ...[/I][/INDENT] But they go on to add: [INDENT][I]This observation needs to be confirmed in future studies. If this is due to hGH suppression, we might anticipate a positive effect of serum glucose, given that hGH may be a causative factor for insulin resistance.[/I][/INDENT] A little more detail in [URL='https://bjui-journals.onlinelibrary.wiley.com/doi/full/10.1111/bju.12363']another piece[/URL]: [INDENT][I]In general, enclomiphene citrate had few changes in these hormones and markers, with the exception of IGF-1. IGF-1 is secreted by the liver and is regulated in part by hGH levels; however circulating levels also are dependent on the proteins that bind IGF-1 in the circulation. IGF-1 levels were decreased in the men in the enclomiphene citrate groups, but not in the transdermal testosterone group, but the levels remained within the normal physiological ranges. We are uncertain as to the significance of this observation. Testosterone treatment of men with testosterone deficiency usually increases serum estradiol levels, and may increase hGH and IGF-1 levels. Estrogen is known to potentiate secretion of hGH and IGF-1 levels. Enclomiphene citrate increases serum estradiol levels. We suspect that the anti-estrogen effects of enclomiphene citrate are working at either the hypothalamic-pituitary level or possibly on the liver to reduce IGF-1 levels. Unfortunately, technical issues prevented the measurement of hGH levels in the serum samples from these men. It would also be relevant to know if enclomiphene citrate treatment affects the IGF-binding proteins.[/I][/INDENT] I tried to dig into the relationship between estrogens and hGH. I found it to be clear as mud. In any case, I think my overall point holds: there's uncertainty about the effects of long-term enclomiphene use. Influence on IGF-1 by whatever route is still demonstrating less-than-ideal selectivity. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Kisspeptin suppression under TRT: Can it affect mood and libido?
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