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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Kisspeptin suppression under TRT: Can it affect mood and libido?
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<blockquote data-quote="BadassBlues" data-source="post: 245245" data-attributes="member: 38526"><p>This appears to state that K10 is potentially ineffective due to a short half life and a molecular size that may not cross the BBB. Then this statement:</p><p></p><p><em><strong>In healthy men, both an intravenous bolus and a continuous infusion of <u>KP-10 produced significant LH responses with the latter maintaining LH secretion for at least 22.5 h</u> [17,25]. Acute and chronic administration of intravenous KP-10-induced LH increases in obese hypogonadal diabetic men [27] and healthy older men [28], thereby highlighting promising therapeutic avenues for the use of kisspeptin in male functional hypogonadism related to diabetes, obesity, or age.</strong></em></p><p></p><p>They reference only IV administration however.</p><p></p><p>There are some interesting animal studies, which I won't post here, that have the same mixed reviews. Good results were seen with constant IV administration. </p><p></p><p>Out of curiosity and a glimmer of hope, I ordered some and will post my personal findings.</p></blockquote><p></p>
[QUOTE="BadassBlues, post: 245245, member: 38526"] This appears to state that K10 is potentially ineffective due to a short half life and a molecular size that may not cross the BBB. Then this statement: [I][B]In healthy men, both an intravenous bolus and a continuous infusion of [U]KP-10 produced significant LH responses with the latter maintaining LH secretion for at least 22.5 h[/U] [17,25]. Acute and chronic administration of intravenous KP-10-induced LH increases in obese hypogonadal diabetic men [27] and healthy older men [28], thereby highlighting promising therapeutic avenues for the use of kisspeptin in male functional hypogonadism related to diabetes, obesity, or age.[/B][/I] They reference only IV administration however. There are some interesting animal studies, which I won't post here, that have the same mixed reviews. Good results were seen with constant IV administration. Out of curiosity and a glimmer of hope, I ordered some and will post my personal findings. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Kisspeptin suppression under TRT: Can it affect mood and libido?
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