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Kidneys and Citrulline
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<blockquote data-quote="hotdog" data-source="post: 145685" data-attributes="member: 12652"><p>Here's some fun facts to be aware of when testing Creatinine level. My thoughts are that since there are pharmaceuticals that raise Creatinine I wonder how many other compounds out there do the same thing. </p><p></p><p><strong>Know the Medications That Spuriously Elevate the Serum Creatinine Level.</strong></p><p></p><p>In a number of scenarios, the serum creatinine level can increase without reflecting a change in the actual GFR. The antibiotic trimethoprim-sulfamethoxazole (<strong>Bactrim</strong>) and the H2-blocker cimetidine are 2 commonly used drugs that decrease the secretion of creatinine. This can result in a self-limited and reversible increase in the serum creatinine level of as much as 0.4 to 0.5 mg/dL (depending on baseline serum creatinine level). Famotidine and ranitidine can likewise cause an increase but to a lesser degree. The antibiotic cefoxitin can spuriously increase the serum creatinine level by interfering with the colorimetric assay used to measure serum creatinine levels.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664589/#R3" target="_blank">3</a> In both instances, the blood urea nitrogen (BUN) typically does not change. As such, an increase in creatinine level suggests a true decrease in GFR only if accompanied by a corresponding increase in BUN levels.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664589/" target="_blank">The Top 10 Things Nephrologists Wish Every Primary Care Physician Knew</a></p></blockquote><p></p>
[QUOTE="hotdog, post: 145685, member: 12652"] Here's some fun facts to be aware of when testing Creatinine level. My thoughts are that since there are pharmaceuticals that raise Creatinine I wonder how many other compounds out there do the same thing. [B]Know the Medications That Spuriously Elevate the Serum Creatinine Level.[/B] In a number of scenarios, the serum creatinine level can increase without reflecting a change in the actual GFR. The antibiotic trimethoprim-sulfamethoxazole ([B]Bactrim[/B]) and the H2-blocker cimetidine are 2 commonly used drugs that decrease the secretion of creatinine. This can result in a self-limited and reversible increase in the serum creatinine level of as much as 0.4 to 0.5 mg/dL (depending on baseline serum creatinine level). Famotidine and ranitidine can likewise cause an increase but to a lesser degree. The antibiotic cefoxitin can spuriously increase the serum creatinine level by interfering with the colorimetric assay used to measure serum creatinine levels.[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664589/#R3']3[/URL] In both instances, the blood urea nitrogen (BUN) typically does not change. As such, an increase in creatinine level suggests a true decrease in GFR only if accompanied by a corresponding increase in BUN levels. [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664589/"]The Top 10 Things Nephrologists Wish Every Primary Care Physician Knew[/URL] [/QUOTE]
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