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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Jatenzo Dosing w/o Food/Meal?
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<blockquote data-quote="MegaTurd" data-source="post: 265668" data-attributes="member: 14271"><p>I've followed Systemlord's progress with Jatenzo. After being on TRT for well over a decade and countless complications from injections, dealing with discontinued products like Androderm or a complete lack of therapeutic effectiveness from alternate modalities like Natesto, I decided to give Jatenzo a shake. I'm on a slightly higher dose: titrated up to 316mg, BID. </p><p></p><p>I recall reading that Systemlord was experimenting with dosing without a meal/food. Curious if he or anyone else out there has experimented and/or observed a significant decrease in levels dosing without a meal? Some of the earlier studies indicated there was a significant decrease when dosing with lower fat meals or on an empty stomach so I'm interested to see what others have discovered.</p><p></p><p>I'm curious about this because I would prefer to dose my PM dose right before bed. At the moment, I try to wrap up eating 3-4 hours before bed so I'm currently dosing Jatenzo between 6-7pm. Studies indicated Tmax is between 2-4 hours, so I'm currently peaking around bedtime and in the high T range while I'm trying to nail some quality delta sleep. Unfortunately, I'm one of those guys whose sleep suffers when my T is high. Soooo... it would be great if I could dose right before bed and peak closer to my wake up time instead... similar to the way Androderm worked... similar to eugonadal circadian production. Right now I'm experiencing the same sleep issue I used to with injections... waking early, warm, adrenaline rush and feeling exhausted the next day. On Natesto and Androderm, this was not a problem nor was it a problem when I was hypogonadal so I'm connecting it to high T levels. </p><p></p><p>Already being treated for UARS with APAP in case someone's brain fires in that direction.</p><p></p><p>In any case, I'll probably experiment myself and see what happens dosing without a meal before bed. One of the advantages of the 316mg dose is that it is comprised of (2) 158mg capsules soooooo... I could reduce my dosage slightly at night as well by just taking a 158mg cap with dinner... should result in lower T levels at bedtime. I've also considered doing the 316 mg PM dose mid afternoon with the thinking that by bedtime I'd prob be in the 400s vs the 700-800s like I am currently dosing with dinner. </p><p></p><p>I'll add that Jatenzo has crushed my SHBG. Historically mine was in the 40s/50s... mid 30s on injections. Latest labs had mine at 11! A little concerned...</p></blockquote><p></p>
[QUOTE="MegaTurd, post: 265668, member: 14271"] I've followed Systemlord's progress with Jatenzo. After being on TRT for well over a decade and countless complications from injections, dealing with discontinued products like Androderm or a complete lack of therapeutic effectiveness from alternate modalities like Natesto, I decided to give Jatenzo a shake. I'm on a slightly higher dose: titrated up to 316mg, BID. I recall reading that Systemlord was experimenting with dosing without a meal/food. Curious if he or anyone else out there has experimented and/or observed a significant decrease in levels dosing without a meal? Some of the earlier studies indicated there was a significant decrease when dosing with lower fat meals or on an empty stomach so I'm interested to see what others have discovered. I'm curious about this because I would prefer to dose my PM dose right before bed. At the moment, I try to wrap up eating 3-4 hours before bed so I'm currently dosing Jatenzo between 6-7pm. Studies indicated Tmax is between 2-4 hours, so I'm currently peaking around bedtime and in the high T range while I'm trying to nail some quality delta sleep. Unfortunately, I'm one of those guys whose sleep suffers when my T is high. Soooo... it would be great if I could dose right before bed and peak closer to my wake up time instead... similar to the way Androderm worked... similar to eugonadal circadian production. Right now I'm experiencing the same sleep issue I used to with injections... waking early, warm, adrenaline rush and feeling exhausted the next day. On Natesto and Androderm, this was not a problem nor was it a problem when I was hypogonadal so I'm connecting it to high T levels. Already being treated for UARS with APAP in case someone's brain fires in that direction. In any case, I'll probably experiment myself and see what happens dosing without a meal before bed. One of the advantages of the 316mg dose is that it is comprised of (2) 158mg capsules soooooo... I could reduce my dosage slightly at night as well by just taking a 158mg cap with dinner... should result in lower T levels at bedtime. I've also considered doing the 316 mg PM dose mid afternoon with the thinking that by bedtime I'd prob be in the 400s vs the 700-800s like I am currently dosing with dinner. I'll add that Jatenzo has crushed my SHBG. Historically mine was in the 40s/50s... mid 30s on injections. Latest labs had mine at 11! A little concerned... [/QUOTE]
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Jatenzo Dosing w/o Food/Meal?
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