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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Is the feeling of "well being" on TRT, dosage dependent?
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<blockquote data-quote="Cataceous" data-source="post: 184137" data-attributes="member: 38109"><p>You did show me that the most credible research found a half-life of about five days for testosterone cypionate. In addition, there have been a few instances of guys reporting two testosterone measurements in an injection cycle, and these have jibed with the five-day half-life figure. So yes, on a 3.5 day cycle there's usually going to be a pronounced trough, and the peak could be as much as 50-60% higher.</p><p></p><p>I also agree that serum testosterone peaks in the first 12 hours post-injection, and maybe much less. With propionate, at two to three hours post-injection I see quite high values, which are around the predicted peak. In modeling the pharmacokinetics of testosterone esters one finds that the major influence on time-to-peak is the half-life of pure testosterone in serum; time-to-peak is relatively insensitive to the half-life of the ester itself.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 184137, member: 38109"] You did show me that the most credible research found a half-life of about five days for testosterone cypionate. In addition, there have been a few instances of guys reporting two testosterone measurements in an injection cycle, and these have jibed with the five-day half-life figure. So yes, on a 3.5 day cycle there's usually going to be a pronounced trough, and the peak could be as much as 50-60% higher. I also agree that serum testosterone peaks in the first 12 hours post-injection, and maybe much less. With propionate, at two to three hours post-injection I see quite high values, which are around the predicted peak. In modeling the pharmacokinetics of testosterone esters one finds that the major influence on time-to-peak is the half-life of pure testosterone in serum; time-to-peak is relatively insensitive to the half-life of the ester itself. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Is the feeling of "well being" on TRT, dosage dependent?
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