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My primary concern is the long-term use of enclomiphene. To what extent is it reducing estrogenic activity in non-target areas? Complaints? It would be nice if it didn't require multiple daily injections. You need determination bordering on compulsion to "stick" with this. However, it's totally worth it to be "fixed up". It's not like it made me 20 again, but it pretty much resolved the issues I was having with TRT, including fading libido and erratic sexual function.