Is it true that low-dose TRT does NOT suppress own production?

[krm]

I‘m currently FURIOUS about my doc. Grrrrrr.... Backstory here.

Anyway - is it true that you can give low-dose TRT as an „add-on“ in a low-enough dose that does not suppress your own production?

My impression was that ANY exogenous test will suppress your own function.

Any studies / medical proofs would be highly welcome.

Thanks!

 

[Weasel]

I‘m currently FURIOUS about my doc. Grrrrrr.... Backstory will follow.

Anyway - is it true that you can give low-dose TRT as an „add-on“ in a low-enough dose that does not suppress your own production?

My impression was that ANY exogenous test will suppress your own function.

Any studies / medical proofs would be highly welcome.

Thanks!

you are correct, your doctor is wrong. Even if your own production does not cease, it will still be suppressed by adding ANY amount of exogenous testosterone.

 

[HarryCat2]

In this study LH and FSH were not fully suppressed.

The efficacy and safety of short-acting testosterone ointment (Glowmin) for late-onset hypogonadism in accordance with testosterone circadian rhythm.

Abstract
INTRODUCTION:
It is well known that there is a reduction of circadian rhythm in blood testosterone levels with aging. Our previous report revealed that 3 mg of short-acting testosterone ointment (Glowmin: GL) elevated serum testosterone levels to within the physiological range for 4-6 h. The aim of this study was to clarify the clinical efficacy and safety of GL used topically once every morning, to enhance the circadian rhythm of testosterone, for late-onset hypogonadism (LOH).

METHODS:
A total of 61 LOH patients received 3 mg of GL topically once a day in the morning on scrotal skin for 24 weeks. The clinical efficacy of GL was evaluated by the aging males symptoms (AMS) scale, and blood sampling tests were measured before and after GL treatment.

RESULTS:
Mean patients age was 55.3 ± 9.2 years old. Total AMS scores at 4, 12, and 24 weeks after GL treatments significantly decreased. The results of sub-analysis of AMS, including psychological, physical, and sexual factors also significantly improved after GL treatments. No severe adverse reactions or abnormal laboratory data were reported.

CONCLUSIONS:
This study shows that TRT for LOH with once daily GL treatment supports testosterone circadian rhythm and should be considered to be an effective and safe therapy for LOH.

 

[HarryCat2]

From the study I posted:

Table 3. Blood screening after GL treatment revealed no
significant difference compared with baseline results.

Before 12 Weeks after 24 Weeks after
LH (mIU/mL) 3.49 ± 2.39 3.19 ± 1.82 3.51 ± 2.57 NS
FSH (mIU/mL) 6.64 ± 7.74 6.65 ± 6.75 6.91 ± 7.26 NS

 

[Nelson Vergel]

If you want to attain total T over 400 ng/dL, you have to dose T high enough. It will suppress LH and FSH. When LH and FSH are not fully suppressed, total T's are less than 350 ng/dL. Natesto and that testosterone ointment above do not achieve TT high enough to make a difference in quality of life.

You can increase T and not suppress LH and FSH by using clomiphene. But many guys do not like the way they feel on that drug.

 

[HarryCat2]

Natesto and that testosterone ointment above do not achieve TT high enough to make a difference in quality of life.

From the study:

Total AMS (aging males symptoms) scores at 4, 12, and 24 weeks after GL treatments significantly decreased. The results of sub-analysis of AMS, including psycho-
logical, physical, and sexual factors also significantly improved after GL treatments. No severe
adverse reactions or abnormal laboratory data were reported.

Total AMS scores before treatment were from 29
to 74 (mean 51.3 ± 9.8). Total AMS scores at 4, 12, and
24 weeks after GL treatments significantly decreased to
42.7 ± 11.6, 40.7 ± 11.2, and 38.8 ± 8.8, respectively
(Figure 1). The results of sub-analysis of AMS, including
psychological, physical, and sexual factors also signifi-
cantly improved after GL treatments (Figures 2–4).

 

[YBWV]

What these LOH guys probably got was a decent increase in their DHT with resultant benefits to cognition, mood and sexual function. Are there Labs for the study?
Glowmin - was that the name of the alien in Cocoon by any chance!

 

[Vince Carter]

Garbage study and you can tell because no one, literally no one, is doing that. 3mg/D on the sack isn't going to change any thing for a guy.

 

[krm]

All - thanks for your answers!

If you want to attain total T over 400 ng/dL, you have to dose T high enough. It will suppress LH and FSH. When LH and FSH are not fully suppressed, total T's are less than 350 ng/dL. Natesto and that testosterone ointment above do not achieve TT high enough to make a difference in quality of life.

You can increase T and not suppress LH and FSH by using clomiphene. But many guys do not like the way they feel on that drug.

Nelson - you quote very specific numbers. Do you remember where you got them from? Thanks!