Is estradiol 32 high enough to consider AI? Reference range 8~35

iwasthatkid

New Member
Hi guys,


I got my blood work back and posted the results in my previous post. The number seem good except that my E2 sensitive is at 31.5 with reference range 8~35.


The blood work was done one day before an injection and I do 2 injections a week. So I guess my E2 is probably kinda stable throughout the week?



My weekly dose is 150mg T and 1000iu HCG.



So should I take low dose AI to lower the E2? The 31.5 number is not crazy high but I'm feeling tired constantly. And my nipples are definitely getting sensitive and bigger.


And my E2 was 15 prior to TRT. I wonder if that's a natural level for me to be at?


By the way, my body does not seem to be sensitive to AI. Last year, my urologist put me on Arimidex 0.25mg/day, 3 days/week for 5 weeks. He did not test for E2 sensitive but regular estrogen before and after. My estrogen went up from 137 to 141 though.....I do not know why.....





 
Hi guys,


I got my blood work back and posted the results in my previous post. The number seem good except that my E2 sensitive is at 31.5 with reference range 8~35.


The blood work was done one day before an injection and I do 2 injections a week. So I guess my E2 is probably kinda stable throughout the week?



My weekly dose is 150mg T and 1000iu HCG.



So should I take low dose AI to lower the E2? The 31.5 number is not crazy high but I'm feeling tired constantly. And my E2 was 15 prior to TRT. I wonder if that's a natural level for me to be at.


By the way, my body does not seem to be sensitive to AI. Last year, my urologist put me on Arimidex 0.25mg/day, 3 days/week for 5 weeks. He did not test for E2 sensitive but regular estrogen before and after. My estrogen went up from 137 to 141 though.....I do not know why.....






In the absence of any symptoms of high estradiol I would not add an AI to your protocol. You feeling tired can be caused by so many different things that more comprehensive blood work and lifestyle analysis is warranted. You haven’t given enough information for us to try to help you more. But solely based on that estradiol levels I would not add an AI. You might wanna try to lower you dosage depending on your testosterone levels (that will bring down estradiol and then you can access how you feel without messing with an AI unnecessarily)
 
Just saw you blood work from a different post. You have room to lower you dosage. FT 31 you might try to get it down to low mid 20s. That will bring down your estradiol.
Your DHEA-S is very high (that happened to me once when adding HCG to my protocol). If you are taking DHEA i would reduce the dosage substantially and aim for DHEA-S ~ 400
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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