ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
Is DHT the Cause of BPH ( Prostate Enlargement ) or is it Estradiol?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 79005" data-attributes="member: 3"><p><span style="font-size: 12px"><strong>Serum Steroid and Sex Hormone-Binding Globulin Concentrations and the Risk of Incident Benign Prostatic Hyperplasia: Results From the Prostate Cancer Prevention Trial </strong></span></p><p></p><p>Alan R. Kristal Jeannette M. Schenk YoonJu Song Kathryn B. Arnold Marian L. Neuhouser Phyllis J. Goodman Daniel W. Lin Frank Z. Stanczyk Ian M. Thompson</p><p></p><p>American Journal of Epidemiology, Volume 168, Issue 12, 15 December 2008, Pages 1416&#8211;1424.</p><p></p><p></p><p>Abstract</p><p>The authors conducted a nested case-control study of serum steroid concentrations and risk of benign prostatic hyperplasia (BPH), using data from the placebo arm of the Prostate Cancer Prevention Trial (1993&#8211;2003). Incident BPH over 7 years (n&#8201;=&#8201;708) was defined as receipt of treatment, a report of 2 International Prostate Symptom Score (IPSS) values greater than 14, or 2 increases of 5 or more from baseline IPSS values with at least 1 value greater than or equal to 12. Controls (n&#8201;=&#8201;709) were selected from men who reported no BPH treatment or any IPSS greater than 7. Baseline serum was analyzed for testosterone, estradiol, estrone, 5&#945;-androstane-3&#945;, 17&#946;-diol-glucuronide, and sex hormone-binding globulin. Covariate-adjusted odds ratios contrasting the highest quartiles with the lowest quartiles of testosterone, estradiol, and testosterone:17&#946;-diol-glucuronide ratio were 0.64 (95% confidence interval (CI): 0.43, 0.95; Ptrend&#8201;=&#8201;0.04), 0.72 (95% CI: 0.53, 0.98; Ptrend&#8201;=&#8201;0.09), and 0.64 (95% CI: 0.46, 0.89; Ptrend&#8201;=&#8201;0.004), respectively. Findings did not differ by age, body mass index, time to BPH endpoint, or type of BPH endpoint. H<strong>igh testosterone levels, estradiol levels, and testosterone:17&#946;-diol-glucuronide ratio are associated with reduced BPH risk, which may reflect decreased activity of 5-&#945;-reductase. Genetic or environmental factors that affect the activity of 5-&#945;-reductase may be important in the development of symptomatic BPH.</strong></p><p></p><p></p><p></p><p></p><p>"Whether or not there is a relation of estrogens with BPH risk remains uncertain. Gann et al. (35) reported a positive association between estradiol and incident BPH surgery but only among men with low testosterone and only after controlling for estrone, which suggests that the strong collinearity of estrone and estradiol may have yielded an unstable statistical model. Rohrmann et al. (29) reported a positive association of estradiol with lower urinary tract symptoms. In contrast, both we and others (26, 27) found that estradiol was significantly and negatively associated with BPH. The prostate expresses both estrogen receptor &#946; (in epithelium, where it inhibits growth) and estrogen receptor &#945; (in stroma, where it promotes growth). There is little evidence that estrogen receptor &#945; has a role in BPH (47), and thus a growth-inhibitory effect of estradiol could be consistent with reduced BPH risk. It is also possible that a high estradiol level simply reflects a high testosterone level, because estradiol in older men is almost exclusively formed by aromatization of testosterone. This picture is further complicated by observations in the Prostate Cancer Prevention Trial (48) and other studies (49&#8211;51) that abdominal obesity is a risk factor for BPH, because abdominal obesity also increases estradiol levels. Additional studies of the effects of estradiol on BPH pathogenesis are needed."</p><p></p><p><a href="https://academic.oup.com/aje/article/168/12/1416/155496/Serum-Steroid-and-Sex-Hormone-Binding-Globulin" target="_blank">Full paper</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 79005, member: 3"] [SIZE=3][B]Serum Steroid and Sex Hormone-Binding Globulin Concentrations and the Risk of Incident Benign Prostatic Hyperplasia: Results From the Prostate Cancer Prevention Trial [/B][/SIZE] Alan R. Kristal Jeannette M. Schenk YoonJu Song Kathryn B. Arnold Marian L. Neuhouser Phyllis J. Goodman Daniel W. Lin Frank Z. Stanczyk Ian M. Thompson American Journal of Epidemiology, Volume 168, Issue 12, 15 December 2008, Pages 1416–1424. Abstract The authors conducted a nested case-control study of serum steroid concentrations and risk of benign prostatic hyperplasia (BPH), using data from the placebo arm of the Prostate Cancer Prevention Trial (1993–2003). Incident BPH over 7 years (n = 708) was defined as receipt of treatment, a report of 2 International Prostate Symptom Score (IPSS) values greater than 14, or 2 increases of 5 or more from baseline IPSS values with at least 1 value greater than or equal to 12. Controls (n = 709) were selected from men who reported no BPH treatment or any IPSS greater than 7. Baseline serum was analyzed for testosterone, estradiol, estrone, 5α-androstane-3α, 17β-diol-glucuronide, and sex hormone-binding globulin. Covariate-adjusted odds ratios contrasting the highest quartiles with the lowest quartiles of testosterone, estradiol, and testosterone:17β-diol-glucuronide ratio were 0.64 (95% confidence interval (CI): 0.43, 0.95; Ptrend = 0.04), 0.72 (95% CI: 0.53, 0.98; Ptrend = 0.09), and 0.64 (95% CI: 0.46, 0.89; Ptrend = 0.004), respectively. Findings did not differ by age, body mass index, time to BPH endpoint, or type of BPH endpoint. H[B]igh testosterone levels, estradiol levels, and testosterone:17β-diol-glucuronide ratio are associated with reduced BPH risk, which may reflect decreased activity of 5-α-reductase. Genetic or environmental factors that affect the activity of 5-α-reductase may be important in the development of symptomatic BPH.[/B] "Whether or not there is a relation of estrogens with BPH risk remains uncertain. Gann et al. (35) reported a positive association between estradiol and incident BPH surgery but only among men with low testosterone and only after controlling for estrone, which suggests that the strong collinearity of estrone and estradiol may have yielded an unstable statistical model. Rohrmann et al. (29) reported a positive association of estradiol with lower urinary tract symptoms. In contrast, both we and others (26, 27) found that estradiol was significantly and negatively associated with BPH. The prostate expresses both estrogen receptor β (in epithelium, where it inhibits growth) and estrogen receptor α (in stroma, where it promotes growth). There is little evidence that estrogen receptor α has a role in BPH (47), and thus a growth-inhibitory effect of estradiol could be consistent with reduced BPH risk. It is also possible that a high estradiol level simply reflects a high testosterone level, because estradiol in older men is almost exclusively formed by aromatization of testosterone. This picture is further complicated by observations in the Prostate Cancer Prevention Trial (48) and other studies (49–51) that abdominal obesity is a risk factor for BPH, because abdominal obesity also increases estradiol levels. Additional studies of the effects of estradiol on BPH pathogenesis are needed." [URL="https://academic.oup.com/aje/article/168/12/1416/155496/Serum-Steroid-and-Sex-Hormone-Binding-Globulin"]Full paper[/URL] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
Is DHT the Cause of BPH ( Prostate Enlargement ) or is it Estradiol?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top