Sorry for mentioning both brands of the same ester. Aveed is the brand in the US and Nebido is the brand used outside the US.
Nebido and Aveed are both injectable forms of testosterone undecanoate, a medication used to treat low testosterone levels in men. The main difference between the two is the concentration of the medication in each vial. Nebido contains 1000 mg/4 ml, while Aveed contains 750 mg/3 ml[1][2][3]. They are essentially the same formulation, with different brand names in different countries[2][4].
According to the FDA, the lower dosage of Aveed (750 mg in 3 mL) compared to Nebido (1000 mg in 4 mL) was selected by the manufacturer in an attempt to reduce the volume of the injection[1]. Aveed is the same formulation as Nebido, but it allows for a longer interval between treatments, with injections every 10 weeks compared with every 2-4 weeks for other injectable testosterone products[2][3]. The dosing schedule for Aveed involves a single 3-mL (750 mg) intramuscular injection given once at initiation of therapy, at 4 weeks, and then every 10 weeks thereafter[3]
Like any testosterone product injected in larger volumes and deeply into muscle, Aveed carries a risk of pulmonary oil microembolism (POME), a serious but rare side effect that causes coughing spell after the injection. That’s why the FDA requires patients to go to see their doctor for every injection.
I suggest to anyone using either brand to get their own T tests the day before the third injection to avoid assuming that the injection frequency is adequate. Don’t wait to just get tested by your doctor. Most don’t titrate the dose and just follow the package insert.