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On all of the peptides except IPA there is a definite diminishing returns effect on the dosing over saturation which is 1mcg/kg. What we found out is that if you double 100mcg and go 200, you will only get a 50% increase.  If you triple that dose you will only get around a 25% increase.  Beyond that you get nothing more.  The biggest problem with going up too high on the GHRPs (except IPA) is receptor desensitization and cortisol/prolactin side-effects. Again, IPA is the only one that does not cause any of the typical side effects so high doses are not a problem.  Hexarelin on the other hand, has the highest potential to increase cortisol & prolactin and can occur even at saturation doses.  So it is best to take days off when using this.  In my experience using IPA, I would start at 500mcg and go up.