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Ardoc - that's a concern for some guys.  If you're a younger guy, let's say 43 years old and plan to live another 40 years. We'll that's another 4,000 holes poked in your muscles over the next 40 years. You can mitigate it by going with a 31 GA 5/16" or a 29 GA 1/2" needle, but you gotta think maybe in what year 15 of 40 you'll start feeling some scar tissue buildup. You don't hear many guys complaining about scar tissue. Most guys seem like they've been on TRT for only a few years. The few who we know have been on forever don't seem to voice any concerns.  There's risk in everything, and many consider scar tissue a small risk for the benefits of properly administered TRT.