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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Inflammation: Do you measure c-reactive HS-CRP?
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<blockquote data-quote="DragonBits" data-source="post: 145169" data-attributes="member: 18023"><p>Inflammation; often talked about, but seldom measured. Inflammation is key to many problems, but I seldom see people here either measure C-reactive protein (CRP) or talk about CRP. </p><p></p><p>(Most of us would need to use the High-sensitivity C-reactive protein (HS-CRP) test unless we have an autoimmune disease like Crohn's that causes a much higher CRP.)</p><p></p><p>The hsCRP test is fairly cheap ($30-$35), and it’s listed among the top ten important tests life extension recommend people get.</p><p></p><p>hsCRP isn’t the only inflammation markers, but it appears it is downstream of most all other markers of inflammation. IE: Cytokines like Interleukin-1 beta (IL-1β) should cause higher CRP.</p><p></p><p>hsCRP is non-specific, meaning it could be higher because you have an infection, vascular disease, autoimmune conditions, smoking, high blood pressure, and high blood sugar just to mention a few causes. Even intensive exercise such as a 3-hour run can cause a significant short term rise in HS-CRP, from 2 >12. Hs-CRP is a very general indication of inflammation somewhere in your body. </p><p></p><p>The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers</p><p></p><p><a href="https://pdf.sciencedirectassets.com/271027/1-s2.0-S0735109705X01395/1-s2.0-S0735109705004705/main.pdf?x-amz-security-token=AgoJb3JpZ2luX2VjEMj%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIGeLoDO43grEuES2jjQ2TIAndYVuqLCSgw8klVY2o5ZSAiEA0hgqDKgf4xGIUFshBCalHpndTHLfl9nxlA%2FLkF3bNmgq4wMIkP%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARACGgwwNTkwMDM1NDY4NjUiDB1%2FKBQOvS0k5p%2BxlSq3A%2ByRYmEys2aYqayikhNUiekUomSQlI9t6pm4fe%2FsyWz%2FutWNfn0yXtUXlHElLSMCUHgFIvDmu7thndGQ6gpVjI5BE%2FrFPSYtq54c4JlKHlcmyu14%2BHGJTJcISte37JawsBUfzmZoDZXkhQCaX5ut0jXhTqwank4%2BtdFYQsFpsukDZzG5jWpaLgolpStwbztzdDOmNCQXgLNExP8u2cJhGZxOOu7XbO3mhorc8s1mfhg3Ym%2BDumGEIWZG4C%2FsKrswnyPFG0LWjz4QK9q62UjKnWqTR4h%2BNrGHvE6skszOrBa%2FBMedvwqDKWUaaR9uy4RexCgPqQNyJrBSbe3ASGRQmI8%2FsCeY1y42Hy%2FTP5zT8fTj9Fq0U7PfDFVxFFEFcOqIvIyUyPyLD%2FQzbA752PYE7%2BW55rTRGFGjbRLQJ%2Bfjr0VzzjBWZJVeTCC2PcbqR7UzCvRJcl0jlogva4WXAx2V5a61S8eeVcmaUE7b9BdaOYIr7608kR5m3FHnLrgN33EQ09vEwH%2FkM04pduHV%2Fui08gxN0fx4%2ByiY1Ob10EAjFU5NOo8nS534XUHzaOG721kyQKvp3w%2B4wXEw1LC95QU6tAG%2FIY4MN%2Fxjxn1m40%2B6H7nu8rqgNtT0ftWUTCnR3%2FqKvi0krSs5Fn6DVqzxWGuZQ94JtWa3kLGtAm4ZKMgcXYZy3k15IHb2Zv0NowveY1zLEM0kkQGX9XT5%2BYxrWk7iwr%2BjHbzgkvb4U7gu%2FwCkED6HN4Bm2MkQM7fhy6nRihEKmc2hJf2%2FKIaDXCKRHSyoOmY0ZezLpb4ETkdtvFFe5Fb65DvMOEvLxZ39GgdRq6O4JYK6Evo%3D&AWSAccessKeyId=ASIAQ3PHCVTYQRYYZ4SG&Expires=1554999945&Signature=rllPykthDQKBd54uYOsPtZMvqMw%3D&hash=e550074476bf4260e89a4ed1632c54e18eaf0f622cca55ee936fd15bbd737a13&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0735109705004705&tid=spdf-54c5cc9f-d672-4b97-a185-57a23dc7dfa6&sid=e9c9f23e5be9004ef4297ac20cf0796345f1gxrqa&type=client" target="_blank">Exercise and hs-CRP</a></p><p></p><p>Though greater exercise capacity results in a lower hsCRP.</p><p></p><p>I have been able to lower my hs-CRP significantly over the last year, though there have been so many changes it would be hard to pinpoint any key change. Besides starting TRT, I lost 30 lbs. of weight, lowered my A1C from 5.8>5,2, raised HDL from 36>55, lowered Trig from 178>96m, increased exercise capacity and took several supplements like aged garlic, turmeric, baby aspirin and 5oz of wine a night. I was on and off metformin, I have yet to test what if anything changed while I have been off it. My BG seems well controlled even without metF. I was also on several courses of 10-day antibiotics when I had some periodontal work. So, any combination of those items can have an effect.</p><p></p><p>1/5/2018 3.49 mg/L</p><p>4/21/2018 2.01 mg/L</p><p>9/24/2018 1.75 mg/L</p><p>2/4/2019 1.44 mg/L</p><p>3/9/20190 0.6 mg/L</p><p></p><p>Have many here have measured their hs-CRP, and if not, why not? If you have measured it, was it above 1? Above 1 is a higher risk of CVD.</p><p></p><p>I didn't see this as a topic and thought is should be an important part of at least initial blood tests.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 145169, member: 18023"] Inflammation; often talked about, but seldom measured. Inflammation is key to many problems, but I seldom see people here either measure C-reactive protein (CRP) or talk about CRP. (Most of us would need to use the High-sensitivity C-reactive protein (HS-CRP) test unless we have an autoimmune disease like Crohn's that causes a much higher CRP.) The hsCRP test is fairly cheap ($30-$35), and it’s listed among the top ten important tests life extension recommend people get. hsCRP isn’t the only inflammation markers, but it appears it is downstream of most all other markers of inflammation. IE: Cytokines like Interleukin-1 beta (IL-1β) should cause higher CRP. hsCRP is non-specific, meaning it could be higher because you have an infection, vascular disease, autoimmune conditions, smoking, high blood pressure, and high blood sugar just to mention a few causes. Even intensive exercise such as a 3-hour run can cause a significant short term rise in HS-CRP, from 2 >12. Hs-CRP is a very general indication of inflammation somewhere in your body. The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers [URL='https://pdf.sciencedirectassets.com/271027/1-s2.0-S0735109705X01395/1-s2.0-S0735109705004705/main.pdf?x-amz-security-token=AgoJb3JpZ2luX2VjEMj%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIGeLoDO43grEuES2jjQ2TIAndYVuqLCSgw8klVY2o5ZSAiEA0hgqDKgf4xGIUFshBCalHpndTHLfl9nxlA%2FLkF3bNmgq4wMIkP%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARACGgwwNTkwMDM1NDY4NjUiDB1%2FKBQOvS0k5p%2BxlSq3A%2ByRYmEys2aYqayikhNUiekUomSQlI9t6pm4fe%2FsyWz%2FutWNfn0yXtUXlHElLSMCUHgFIvDmu7thndGQ6gpVjI5BE%2FrFPSYtq54c4JlKHlcmyu14%2BHGJTJcISte37JawsBUfzmZoDZXkhQCaX5ut0jXhTqwank4%2BtdFYQsFpsukDZzG5jWpaLgolpStwbztzdDOmNCQXgLNExP8u2cJhGZxOOu7XbO3mhorc8s1mfhg3Ym%2BDumGEIWZG4C%2FsKrswnyPFG0LWjz4QK9q62UjKnWqTR4h%2BNrGHvE6skszOrBa%2FBMedvwqDKWUaaR9uy4RexCgPqQNyJrBSbe3ASGRQmI8%2FsCeY1y42Hy%2FTP5zT8fTj9Fq0U7PfDFVxFFEFcOqIvIyUyPyLD%2FQzbA752PYE7%2BW55rTRGFGjbRLQJ%2Bfjr0VzzjBWZJVeTCC2PcbqR7UzCvRJcl0jlogva4WXAx2V5a61S8eeVcmaUE7b9BdaOYIr7608kR5m3FHnLrgN33EQ09vEwH%2FkM04pduHV%2Fui08gxN0fx4%2ByiY1Ob10EAjFU5NOo8nS534XUHzaOG721kyQKvp3w%2B4wXEw1LC95QU6tAG%2FIY4MN%2Fxjxn1m40%2B6H7nu8rqgNtT0ftWUTCnR3%2FqKvi0krSs5Fn6DVqzxWGuZQ94JtWa3kLGtAm4ZKMgcXYZy3k15IHb2Zv0NowveY1zLEM0kkQGX9XT5%2BYxrWk7iwr%2BjHbzgkvb4U7gu%2FwCkED6HN4Bm2MkQM7fhy6nRihEKmc2hJf2%2FKIaDXCKRHSyoOmY0ZezLpb4ETkdtvFFe5Fb65DvMOEvLxZ39GgdRq6O4JYK6Evo%3D&AWSAccessKeyId=ASIAQ3PHCVTYQRYYZ4SG&Expires=1554999945&Signature=rllPykthDQKBd54uYOsPtZMvqMw%3D&hash=e550074476bf4260e89a4ed1632c54e18eaf0f622cca55ee936fd15bbd737a13&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0735109705004705&tid=spdf-54c5cc9f-d672-4b97-a185-57a23dc7dfa6&sid=e9c9f23e5be9004ef4297ac20cf0796345f1gxrqa&type=client']Exercise and hs-CRP[/URL] Though greater exercise capacity results in a lower hsCRP. I have been able to lower my hs-CRP significantly over the last year, though there have been so many changes it would be hard to pinpoint any key change. Besides starting TRT, I lost 30 lbs. of weight, lowered my A1C from 5.8>5,2, raised HDL from 36>55, lowered Trig from 178>96m, increased exercise capacity and took several supplements like aged garlic, turmeric, baby aspirin and 5oz of wine a night. I was on and off metformin, I have yet to test what if anything changed while I have been off it. My BG seems well controlled even without metF. I was also on several courses of 10-day antibiotics when I had some periodontal work. So, any combination of those items can have an effect. 1/5/2018 3.49 mg/L 4/21/2018 2.01 mg/L 9/24/2018 1.75 mg/L 2/4/2019 1.44 mg/L 3/9/20190 0.6 mg/L Have many here have measured their hs-CRP, and if not, why not? If you have measured it, was it above 1? Above 1 is a higher risk of CVD. I didn't see this as a topic and thought is should be an important part of at least initial blood tests. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Inflammation: Do you measure c-reactive HS-CRP?
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