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General Health & Fitness
Nutrition and Supplements
Increasing NAD+
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<blockquote data-quote="JPB" data-source="post: 145082" data-attributes="member: 2659"><p>Please listen to the show, it supports my position completely. Will is telling more "true lies" by snipping portions out-of-context. Masterjohn clearly states only trace negligible amounts NR get absorbed past the liver. The liver converts all the precursors to its own NAD pool. If the liver innately senses the need to distribute NAM, it converts the NAD back to NAM. Masterjohn likes NR because he rationalizes it is a better liver substrate for NAM than NAM itself, not because any NR circulates to the tissues. References regarding muscle absorption have to do with a questionable mouse study. The NR was still being distributed as NAM, only the liver was innately determining the timing of the distribution vs. exogenous NAM. Again, oral NR only serves as a substrate for NAM distribution by the liver. NR in the blood is not absorbed by all tissues, most importantly the brain, one of the most important areas for NAD+ consideration. Regarding NAM, the counter argument is a large dose of NAM becomes a liability for the body due to the need to convert it, and some interim suppressive effects on other repair pathways. This comes down to issues of dosage and timing as I have already addressed. Keep dosages at reasonable levels and do not try to keep NAM levels high 24x7. If you have issues with methylation consider adding some methyl donors such as TMG or creatine.</p></blockquote><p></p>
[QUOTE="JPB, post: 145082, member: 2659"] Please listen to the show, it supports my position completely. Will is telling more "true lies" by snipping portions out-of-context. Masterjohn clearly states only trace negligible amounts NR get absorbed past the liver. The liver converts all the precursors to its own NAD pool. If the liver innately senses the need to distribute NAM, it converts the NAD back to NAM. Masterjohn likes NR because he rationalizes it is a better liver substrate for NAM than NAM itself, not because any NR circulates to the tissues. References regarding muscle absorption have to do with a questionable mouse study. The NR was still being distributed as NAM, only the liver was innately determining the timing of the distribution vs. exogenous NAM. Again, oral NR only serves as a substrate for NAM distribution by the liver. NR in the blood is not absorbed by all tissues, most importantly the brain, one of the most important areas for NAD+ consideration. Regarding NAM, the counter argument is a large dose of NAM becomes a liability for the body due to the need to convert it, and some interim suppressive effects on other repair pathways. This comes down to issues of dosage and timing as I have already addressed. Keep dosages at reasonable levels and do not try to keep NAM levels high 24x7. If you have issues with methylation consider adding some methyl donors such as TMG or creatine. [/QUOTE]
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Increasing NAD+
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